Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction
文献类型：期刊论文
| 作者 | Zhang, Zeting2; Jiang, Xin1,2; Xu, Danrui1,2; Zheng, Wenwen1,2; Liu, Maili2; Li, Conggang2 |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 1860期号:9页码:1848-1853 |
| 关键词 | Alpha-synuclein Ca2++ Nmr Spectroscopy Membrane Binding Snare-mediated Membrane Fusion |
| ISSN号 | 0005-2736 |
| DOI | 10.1016/j.bbamem.2018.03.025 |
| 文献子类 | Article |
| 英文摘要 | alpha-Synuclein is involved in Parkinson's disease, and its interaction with cell membrane is vital to its pathological and physiological functions. We have shown that Ca2+ can regulate alpha-synuclein membrane interaction, but the physiological role of Ca2+ in modulating alpha-synuclein membrane interaction is still unexplored. Based on the previous findings that alpha-synuclein inhibits membrane fusion and its inhibitory effect is highly related to its membrane binding, here we employed solution state Nuclear Magnetic Resonance (NMR) spectroscopy and the ensemble fluorescence fusion assay to show that Ca2+ can modulate the inhibitory effect of alpha-synuclein on SNARE-mediated membrane fusion through disrupting alpha-synuclein membrane interaction, resulting in acceleration of SNARE-mediated membrane fusion. These results suggest a modulatory effect of Ca2+ on membrane mediated normal function of alpha-synuclein, which of importance for the study of the Parkinson's disease. |
| WOS关键词 | SOLUTION NMR-SPECTROSCOPY ; NEUROTRANSMITTER RELEASE ; VESICLE DOCKING ; BINDING ; PROTEIN ; FUSION ; AGGREGATION ; EXOCYTOSIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000442333600025 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/13056]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Li, Conggang |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zeting,Jiang, Xin,Xu, Danrui,et al. Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2018,1860(9):1848-1853. |
| APA | Zhang, Zeting,Jiang, Xin,Xu, Danrui,Zheng, Wenwen,Liu, Maili,&Li, Conggang.(2018).Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1860(9),1848-1853. |
| MLA | Zhang, Zeting,et al."Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1860.9(2018):1848-1853. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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