Schizophrenia-like olfactory dysfunction induced by acute and postnatal phencyclidine exposure in rats
文献类型：期刊论文
| 作者 | Shan, Liang2,4; Liu, Tiane2; Zhang, Zhijian3; Liu, Qing3; Zhang, Mengjiao2; Zhao, Xudong2; Zhang, Yan4; Xu, Fuqiang3,5; Ma, Yuanye1,2 |
| 刊名 | SCHIZOPHRENIA RESEARCH
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 199页码:274-280 |
| ISSN号 | 0920-9964 |
| 关键词 | Schizophrenia model Phencyclidine treatment Olfactory dysfunction Local field potential Neural connections |
| DOI | 10.1016/j.schres.2018.02.045 |
| 英文摘要 | Deficits in olfactory abilities are frequently observed in schizophrenia patients. However, whether olfactory dysfunction is found in animal models is not known. Here, we examined whether two well-established schizophrenia rat models exhibit olfactory-relevant dysfunction that is similar to schizophrenia patients. Olfactory sensitivity was tested in rats that were acutely (3.3 mg/kg) or postnatally (10 mg/kg, at postnatal day 7, 9 and 11) treated with phencyclidine (PCP) as schizophrenia models. Electrophysiological recordings were conducted to measure the olfactory-relevant local field potential after acute PCP treatment. Olfactory-relevant neural connections were tested via virus tracing in rats postnatally treated with PCP. We also assessed the reversal effects of olanzapine (OLZ) treatment on both models. We found that acute PCP treatment induced a decline in olfactory sensitivity (p=0.01) and significantly lower beta- and higher gamma-band oscillations (p=0.03, and p=0.00 respectively) which were partly attenuated by OLZ treatment (2 mg/kg and 4 mg/kg). Postnatal PCP exposure also resulted in an olfactory sensitivity deficit during adulthood (p=0.012 for males and p=0.009 for females), and an abnormal development of neural circuits (p=0.000). Together, our research indicated that olfactory dysfunction found in schizophrenia patients can also be observed on animal models. (c) 2018 Published by Elsevier B.V. |
| WOS关键词 | FUNCTIONAL CONNECTIVITY ; CELL-DEATH ; BULB ; STIMULATION ; PSYCHOSES ; DEFICITS |
| 资助项目 | Ministry of Science and Technology of China[2015CB351701] ; Ministry of Science and Technology of China[2015CB856400] ; National Nature Science Foundation of China[31730039] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000444845900040 |
| 资助机构 | Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Ministry of Science and Technology of China ; Ministry of Science and Technology of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/13104]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Ma, Yuanye |
| 作者单位 | 1.Kunming Univ Sci & Technol, Inst Primate Translat Med, Yunnan Key Lab Primate Biomed Res, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan 430071, Hubei, Peoples R China 4.Peking Univ, PKU IDG McGovern Inst Brain Res, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 5.Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shan, Liang,Liu, Tiane,Zhang, Zhijian,et al. Schizophrenia-like olfactory dysfunction induced by acute and postnatal phencyclidine exposure in rats[J]. SCHIZOPHRENIA RESEARCH,2018,199:274-280. |
| APA | Shan, Liang.,Liu, Tiane.,Zhang, Zhijian.,Liu, Qing.,Zhang, Mengjiao.,...&Ma, Yuanye.(2018).Schizophrenia-like olfactory dysfunction induced by acute and postnatal phencyclidine exposure in rats.SCHIZOPHRENIA RESEARCH,199,274-280. |
| MLA | Shan, Liang,et al."Schizophrenia-like olfactory dysfunction induced by acute and postnatal phencyclidine exposure in rats".SCHIZOPHRENIA RESEARCH 199(2018):274-280. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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