Different molecular weight chitosan derivatives employed for enantiomeric separation
文献类型：期刊论文
| 作者 | Qiu, Guo-Song1; Yan, Kui1; Zhang, Shan1; Chen, Wei1; Huang, Shao-Hua2 ; Bai, Zheng-Wu1
|
| 刊名 | ANALYTICAL METHODS
 |
| 出版日期 | 2017-12-14 |
| 卷号 | 9期号:46页码:6560-6568 |
| ISSN号 | 1759-9660 |
| DOI | 10.1039/c7ay02174g |
| 文献子类 | Article |
| 英文摘要 | In the present study, four chitosan (cyclopentylurea)s were synthesized from the chitosans with different viscosity-average molecular weights ranging from 1.2 x 10(5) to 2.1 x 10(5). The chitosan (cyclopentylurea) s were further derivatized with 3,5-dimethylphenyl isocyanate affording chitosan bis(3,5-dimethylphenylcarbamate)-(cyclopentylurea)s which were employed as the chiral selectors for enantiomeric separation. Four chiral stationary phases (CSPs) were prepared with the chiral selectors. The enantioseparation capability of the CSPs was evaluated by high-performance liquid chromatography (HPLC), and the tolerability of the chiral selectors against organic solvents was also tested. These CSPs exhibited satisfactory enantioseparation capabilities in comparison with well-known coated-type CSP of cellulose tris(3,5-dimethylphenylcarbamate), however the capabilities of the four CSPs were not so significantly different. The chiral selectors showed a low swelling capacity in acetone, ethyl acetate and n-hexane/tetrahydrofuran (50/50, v/v), and a medium or high swelling capacity in chloroform and n-hexane/tetrahydrofuran (20/80, v/v). The corresponding CSPs were analyzed with mobile phases using acetone, ethyl acetate and chloroform as additives. The high tolerance to organic solvents reveals that the CSPs have more mobile phase choices for enantiomeric separation. In addition, the influence of one enantiomer of a racemate upon the interaction between the other enantiomer and a chiral selector was studied by HPLC with aid of H-1 NMR measurements. |
| WOS关键词 | CHIRAL STATIONARY PHASES ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; SILICA-GEL ; ENANTIOSEPARATION CHARACTERISTICS ; ALKYL UREA ; CELLULOSE ; AMYLOSE ; CHITIN ; SELECTORS ; ENANTIOSELECTIVITY |
| WOS研究方向 | Chemistry ; Food Science & Technology ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000416947700012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China(51373127) ; Hubei Provincial Department of Education(D20161505) |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/10465]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Chen, Wei |
| 作者单位 | 1.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biobased Mat, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Guo-Song,Yan, Kui,Zhang, Shan,et al. Different molecular weight chitosan derivatives employed for enantiomeric separation[J]. ANALYTICAL METHODS,2017,9(46):6560-6568. |
| APA | Qiu, Guo-Song,Yan, Kui,Zhang, Shan,Chen, Wei,Huang, Shao-Hua,&Bai, Zheng-Wu.(2017).Different molecular weight chitosan derivatives employed for enantiomeric separation.ANALYTICAL METHODS,9(46),6560-6568. |
| MLA | Qiu, Guo-Song,et al."Different molecular weight chitosan derivatives employed for enantiomeric separation".ANALYTICAL METHODS 9.46(2017):6560-6568. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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