Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis
文献类型：期刊论文
| 作者 | Zhang, Weidong1; Zhao, Yong1,2; Li, Fuli3; Li, Lan1; Feng, Yanni1; Min, Lingjiang1; Ma, Dongxue1; Yu, Shuai1; Liu, Jing4; Zhang, Hongfu2 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2018-01-30 |
| 卷号 | 9 |
| 关键词 | Zinc Oxide Nanoparticles Plasma Metabolomics Perturbation Hepatic Steatosis |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2018.00057 |
| 文献子类 | Article |
| 英文摘要 | Zinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption, are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs. However, they have also been found to adversely affect organisms; previously we found that ZnO NPs disrupt pubertal ovarian development, inhibit embryonic development by upsetting gamma-H2AX and NF-kappa B pathways, and even disturb skin stem cells. Non-targeted metabolomic analysis of biological organisms has been suggested as an unbiased tool for the investigation of perturbations in response to NPs and their underlying mechanisms. Although metabolomics has been used in nanotoxicological studies, very few reports have used it to investigate the effects of ZnO NPs exposure. In the current investigation, through a metabolomics-based approach, we discovered that ZnO NPs caused changes in plasma metabolites involved in anti-oxidative mechanisms, energy metabolism, and lipid metabolism in hen livers. These results are in line with earlier findings that ZnO NPs perturb the tricarboxylic acid cycle and in turn result in the use of alternative energy sources. We also found that ZnO NPs disturbed lipid metabolism in the liver and consequently impacted blood lipid balance. Changes in plasma metabolomes were correlated with hepatic steatosis. |
| WOS关键词 | OXIDATIVE STRESS ; INDUCED HEPATOTOXICITY ; TOXICITY ; RATS ; TAURINE ; CELLS ; EXPOSURE ; LUNG ; NEPHROTOXICITY ; CYTOTOXICITY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000423546900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Agricultural Innovative Project of Shandong Academy of Agricultural Sciences(CXGC2017B02) ; Program for Natural Science Foundation of Shandong Province in China(ZR2015CL045) ; National Natural Science Foundation of China(31302166) ; Qingdao Agricultural University Outstanding Research Foundation |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/10585]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Zhao, Yong; Shen, Wei |
| 作者单位 | 1.Qingdao Agr Univ, Coll Life Sci, Qingdao, Peoples R China 2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China 4.Qingdao Agr Univ, Core Labs, Qingdao, Peoples R China 5.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weidong,Zhao, Yong,Li, Fuli,et al. Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis[J]. FRONTIERS IN PHARMACOLOGY,2018,9. |
| APA | Zhang, Weidong.,Zhao, Yong.,Li, Fuli.,Li, Lan.,Feng, Yanni.,...&Shen, Wei.(2018).Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis.FRONTIERS IN PHARMACOLOGY,9. |
| MLA | Zhang, Weidong,et al."Zinc Oxide Nanoparticle Caused Plasma Metabolomic Perturbations Correlate with Hepatic Steatosis".FRONTIERS IN PHARMACOLOGY 9(2018). |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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