Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms
文献类型：期刊论文
| 作者 | Fan, Yong; Meng, Hui-Min; Hu, Guang-Rong; Li, Fu- |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 102期号:7页码:3027-3035 |
| ISSN号 | 0175-7598 |
| 关键词 | Very Long-chain Monounsaturated Fatty Acids Synthetic Biology Metabolic Engineering Cellular Engineering 3-ketoacyl-coa Synthesis |
| DOI | 10.1007/s00253-018-8859-y |
| 文献子类 | Review |
| 英文摘要 | Nervonic acid (NA) is a major very long-chain monounsaturated fatty acid found in the white matter of mammalian brains, which plays a critical role in the treatment of psychotic disorders and neurological development. In the nature, NA has been synthesized by a handful plants, fungi, and microalgae. Although the metabolism of fatty acid has been studied for decades, the biosynthesis of NA has yet to be illustrated. Generally, the biosynthesis of NA is considered starting from oleic acid through fatty acid elongation, in which malonyl-CoA and long-chain acyl-CoA are firstly condensed by a rate-limiting enzyme 3-ketoacyl-CoA synthase (KCS). Heterologous expression of kcs gene from high NA producing species in plants and yeast has led to synthesis of NA. Nevertheless, it has also been reported that desaturases in a few plants can catalyze very long-chain saturated fatty acid into NA. This review highlights recent advances in the biosynthesis, the sources, and the biotechnological aspects of NA. |
| WOS关键词 | DNA-POLYMERASE-BETA ; RATE-LIMITING STEP ; CHAIN FATTY-ACIDS ; SACCHAROMYCES-CEREVISIAE ; ARABIDOPSIS-THALIANA ; YARROWIA-LIPOLYTICA ; GENE FAMILY ; 3-KETOACYL-COA SYNTHASES ; SUBSTRATE-SPECIFICITY ; MORTIERELLA-ALPINA |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000427579600008 |
| 资助机构 | National Natural Science Foundation of China(31602154) ; Shandong Province Natural Science Major Program(ZR2017ZB0209) ; Shandong Province Natural Science Funds for Young Scholar(JQ201507 ; ZR2017BC108) |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/10673]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Li, Fu- |
| 作者单位 | Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao Engn Lab Single Cell Oil, Shandong Prov Key Lab Synthet Biol,Key Lab Biofue, 189 Songling Rd, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yong,Meng, Hui-Min,Hu, Guang-Rong,et al. Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018,102(7):3027-3035. |
| APA | Fan, Yong,Meng, Hui-Min,Hu, Guang-Rong,&Li, Fu-.(2018).Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,102(7),3027-3035. |
| MLA | Fan, Yong,et al."Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 102.7(2018):3027-3035. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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