Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery
文献类型：期刊论文
| 作者 | Bai, Xiaoyu1; Bao, Zixian2; Bi, Shichao1; Li, Yang1; Yu, Xiaoping1; Hu, Shihao1; Tian, Meiping1; Zhang, Xin1; Cheng, Xiaojie1; Chen, Xiguang1,3 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 18期号:3 |
| 关键词 | Hydrogel Hydroxybutyl Chitosan Oral Delivery Thermo Ph Double Sensitive |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201700305 |
| 文献子类 | Article |
| 英文摘要 | A series of thermo/pH sensitive N-succinyl hydroxybutyl chitosan (NSHBC) hydrogels with different substitution degrees of succinyl are prepared for drug delivery. Rheology analysis shows that the gelation temperature of NSHBC hydrogels is 3.8 degrees C higher than that of hydroxybutyl chitosan (HBC) hydrogels. A model drug bovine serum albumin (BSA) is successfully loaded and released. NSHBC hydrogels show excellent pH sensitivity drug release behaviors. After incubation for 24 h, 93.7% of BSA is released from NSHBC hydrogels in phosphate buffer saline (PBS) (pH 7.4), which is significantly greater than that of 24.6% at pH 3.0. In contrast, the release rate of BSA from HBC is about 70.0% at pH 3.0 and 7.4. Thus, these novel hydrogels have the prominent merits of high adaptability to soluble drugs and pH sensitivity triggered release, indicating that NSHBC hydrogels have promising applications in oral drug delivery. |
| WOS关键词 | N-SUCCINYL-CHITOSAN ; HYDROXYBUTYL CHITOSAN ; ORAL DELIVERY ; THERMOSENSITIVE HYDROGEL ; BIOMEDICAL APPLICATIONS ; CARBOXYMETHYL CHITOSAN ; CONTROLLED-RELEASE ; INSULIN DELIVERY ; CROSS-LINKING ; IN-VITRO |
| WOS研究方向 | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000426736000002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China(81671828) ; China Postdoctoral Science Foundation(2016M592246) ; Taishan Scholar Program, China |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/10687]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Cheng, Xiaojie; Chen, Xiguang |
| 作者单位 | 1.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Qingdao 266000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Xiaoyu,Bao, Zixian,Bi, Shichao,et al. Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery[J]. MACROMOLECULAR BIOSCIENCE,2018,18(3). |
| APA | Bai, Xiaoyu.,Bao, Zixian.,Bi, Shichao.,Li, Yang.,Yu, Xiaoping.,...&Chen, Xiguang.(2018).Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery.MACROMOLECULAR BIOSCIENCE,18(3). |
| MLA | Bai, Xiaoyu,et al."Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery".MACROMOLECULAR BIOSCIENCE 18.3(2018). |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。