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Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis

文献类型：期刊论文

作者Liu, Changshui1,2; Ding, Yamei2; Xian, Mo1; Liu, Min1; Liu, Huizhou1; Ma, Qingjun2; Zhao, Guang1
刊名CRITICAL REVIEWS IN BIOTECHNOLOGY
出版日期2017
卷号37期号:7页码:933-941
关键词3-hydroxypropionate Malonyl-coa Pathway Metabolic Engineering Acetyl-coa Carboxylase Malonyl-coa Reductase Carbon Flux Enzyme Engineering Supply Of Energy And cOfactor 3hp Tolerance
DOI10.1080/07388551.2016.1272093
文献子类Review
英文摘要3-Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a biodegradable plastic. To establish a sustainable way to produce these commercially important chemicals and materials, fermentative production of 3HP is widely investigated in recent years. It is reported that 3HP can be produced from several intermediates, such as glycerol, malonyl-CoA, and beta-alanine. Among all these biosynthetic routes, the malonyl-CoA pathway has some distinct advantages, including a broad feedstock spectrum, thermodynamic feasibility, and redox neutrality. To date, this pathway has been successfully constructed in various species including Escherichia coli, yeast and cyanobacteria, and optimized through carbon flux redirection, enzyme screening and engineering, and an increasing supply of energy and cofactors, resulting in significantly enhanced 3HP titer up to 40 g/L. These results show the feasibility of commercial manufacturing of 3HP and its derivatives in the future.
WOS关键词RECOMBINANT ESCHERICHIA-COLI ; AUTOTROPHIC CARBON FIXATION ; COENZYME-A REDUCTASE ; ACETYL-COA ; CHLOROFLEXUS-AURANTIACUS ; SACCHAROMYCES-CEREVISIAE ; PYROCOCCUS-FURIOSUS ; ACID PRODUCTION ; FATTY-ACIDS ; ACETATE
WOS研究方向Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:000407365200009
资助机构100-Talent Project of CAS ; CAS Key Program(ZDRW-ZS-2016-3M) ; Taishan Scholars Climbing Program of Shandong(TSPD20150210) ; National Natural Science Foundation of China(31670089)
源URL[http://ir.qibebt.ac.cn/handle/337004/9546]  
专题青岛生物能源与过程研究所_材料生物技术研究中心
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Changshui,Ding, Yamei,Xian, Mo,et al. Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2017,37(7):933-941.
APA Liu, Changshui.,Ding, Yamei.,Xian, Mo.,Liu, Min.,Liu, Huizhou.,...&Zhao, Guang.(2017).Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis.CRITICAL REVIEWS IN BIOTECHNOLOGY,37(7),933-941.
MLA Liu, Changshui,et al."Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis".CRITICAL REVIEWS IN BIOTECHNOLOGY 37.7(2017):933-941.

入库方式： OAI收割

来源：青岛生物能源与过程研究所

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