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Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken
文献类型：期刊论文
| 作者 | Gao, Pengfei3; Ma, Chen3; Sun, Zheng1,2; Wang, Lifeng3; Huang, Shi1,2; Su, Xiaoquan1,2; Xu, Jian1,2; Zhang, Heping3 |
| 刊名 | MICROBIOME
 |
| 出版日期 | 2017-08-03 |
| 卷号 | 5 |
| 关键词 | Probiotics Intestinal Microbiota Broiler Antibiotic Overuse Antibiotic Resistance |
| DOI | 10.1186/s40168-017-0315-1 |
| 文献子类 | Article |
| 英文摘要 | Background: Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals. Results: Host phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio (FCR) and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus, "intestinal microbiota maturation index" was proposed to quantitatively compare impact of feed additives on animal microecology. Conclusions: Our results reveal a tremendous potential of probiotics as antibiotics' substitute in poultry farming. |
| WOS关键词 | CECAL MICROFLORA COMPOSITION ; GROWTH-PERFORMANCE ; FECAL MICROBIOTA ; HUMAN HEALTH ; LACTOBACILLUS ; ALTERNATIVES ; PREBIOTICS ; PROMOTERS ; STRAINS ; POULTRY |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000407724000001 |
| 资助机构 | National Natural Science Foundation of China(31430066) |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/9548]  |
| 专题 | 青岛生物能源与过程研究所_单细胞中心 |
| 作者单位 | 1.Chinese Acad Sci, Single Cell Ctr, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Lab Energy Genet, Qingdao 266101, Shandong, Peoples R China 3.Inner Mongolia Agr Univ, Key Lab Dairy Biotechnol & Engn, Hohhot 010018, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Pengfei,Ma, Chen,Sun, Zheng,et al. Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken[J]. MICROBIOME,2017,5. |
| APA | Gao, Pengfei.,Ma, Chen.,Sun, Zheng.,Wang, Lifeng.,Huang, Shi.,...&Zhang, Heping.(2017).Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken.MICROBIOME,5. |
| MLA | Gao, Pengfei,et al."Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken".MICROBIOME 5(2017). |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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