Expansion of chemical space for natural products by uncommon P450 reactions
文献类型：期刊论文
| 作者 | Zhang, Xingwang; Li, Shengying |
| 刊名 | NATURAL PRODUCT REPORTS
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 34期号:9页码:1061-1089 |
| DOI | 10.1039/c7np00028f |
| 文献子类 | Review |
| 英文摘要 | C Cytochrome P450 enzymes (P450s) are the most versatile biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is broadly harnessed by numerous chemical defenders such as bacteria, fungi, and plants for the generation of diverse and complex natural products. Rather than the common tailoring reactions (e.g. hydroxylation and epoxidation) mediated by the majority of biosynthetic P450s, in this review, we will focus on the unusual P450 enzymes in relation to new chemistry, skeleton construction, and structure re-shaping via their own unique catalytic power or the intriguing protein-protein interactions between P450s and other proteins. These uncommon P450 reactions lead to a higher level of chemical space expansion for natural products, through which a broader spectrum of bioactivities can be gained by the host organisms. |
| WOS关键词 | FLAVIOLIN SUBSTRATE MOLECULES ; STREPTOMYCES-COELICOLOR A3(2) ; TROPANE ALKALOID BIOSYNTHESIS ; FATTY-ACID DECARBOXYLASE ; PHENOL COUPLING REACTION ; CYTOCHROME-P450 MONOOXYGENASE ; MULTIFUNCTIONAL CYTOCHROME-P450 ; VANCOMYCIN BIOSYNTHESIS ; COMBINATORIAL BIOSYNTHESIS ; POLYKETIDE SYNTHASE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000409009000003 |
| 资助机构 | National Natural Science Foundation of China(NSFC 31422002) ; Natural Science Foundation of Shandong Province(JQ201407) ; Chinese Academy of Sciences(QYZDB-SSW-SMC042) |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/9558]  |
| 专题 | 青岛生物能源与过程研究所_酶工程团队 |
| 作者单位 | Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xingwang,Li, Shengying. Expansion of chemical space for natural products by uncommon P450 reactions[J]. NATURAL PRODUCT REPORTS,2017,34(9):1061-1089. |
| APA | Zhang, Xingwang,&Li, Shengying.(2017).Expansion of chemical space for natural products by uncommon P450 reactions.NATURAL PRODUCT REPORTS,34(9),1061-1089. |
| MLA | Zhang, Xingwang,et al."Expansion of chemical space for natural products by uncommon P450 reactions".NATURAL PRODUCT REPORTS 34.9(2017):1061-1089. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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