A novel fish collagen scaffold as dural substitute
文献类型：期刊论文
| 作者 | Li, Qing1; Mu, Lanlan1; Zhang, Fenghua1; Sun, Yue2; Chen, Quan2; Xie, Cuicui1; Wang, Hongmei1 |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 80页码:346-351 |
| 关键词 | Fish Collagen Edc Crosslinking Dural Substitute |
| DOI | 10.1016/j.msec.2017.05.102 |
| 文献子类 | Article |
| 英文摘要 | The novel fish collagen scaffolds were prepared by lyophilization. The collagen sponges and chitosan were chemically cross-linked with the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) as a cross-linking agent by pressing in one special mould. The collagen scaffolds were analyzed by scanning electron microscopy (SEM) and mechanical property, and the in vitro collagenase degradation was tested. The results revealed that the scaffold has a suitable porosity, elasticity and prevent fluid leakage, suggesting potential applications in the tissue engineered. In vitro collagenase degradation demonstrated that the collagen cross-linking with EDC by pressing played an important role in their resistance to biodegradation. Moreover, the scaffold proved excellent biocompatibility for the activity and proliferation of mouse embryonic fibroblasts cells (MEFs) in vitro. The rabbit dural defect model demonstrated that the scaffolds could prevent brain tissue adhesion, which reduce the opportunity of inflammation, facilitate the growth of fibroblasts and enhance the tissue regeneration and healing. The novel fish collagen scaffold as dural substitute, demonstrate a capability for using in the field of tissue engineering. (C) 2017 Published by Elsevier B.V. |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000410254400041 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/9742]  |
| 专题 | 青岛生物能源与过程研究所_仿生能源与储能系统团队 |
| 作者单位 | 1.Qingdao Chunghao Tissue Engn Co Ltd, Qingdao 266003, Shandong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qing,Mu, Lanlan,Zhang, Fenghua,et al. A novel fish collagen scaffold as dural substitute[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,80:346-351. |
| APA | Li, Qing.,Mu, Lanlan.,Zhang, Fenghua.,Sun, Yue.,Chen, Quan.,...&Wang, Hongmei.(2017).A novel fish collagen scaffold as dural substitute.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,80,346-351. |
| MLA | Li, Qing,et al."A novel fish collagen scaffold as dural substitute".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 80(2017):346-351. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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