Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
文献类型：期刊论文
| 作者 | Wei Zhang; Baobing Zhao; Liangcheng Du; Yuemao Shen |
| 刊名 | Molecules
 |
| 出版日期 | 2017 |
| 卷号 | 22页码:1547-1555 |
| DOI | doi:10.3390/molecules22091547 |
| 文献子类 | Article |
| 英文摘要 | Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β -unsaturated -lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (50-adenosine monophosphate-activated protein kinase). |
| WOS关键词 | polyketide ; mycoepoxydiene ; cyclooctadiene ; endophtic fungus ; cytotoxicity |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| 资助机构 | NSFC (31570030) ; Youth Innovation Promotion Association CAS to W.Z. (2015166) ; Nebraska Research Initiatives ; China Postdoctoral Science Found (2015M580606 and 2016M580606). |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/9858]  |
| 专题 | 青岛生物能源与过程研究所_酶工程团队 |
| 推荐引用方式 GB/T 7714 | Wei Zhang,Baobing Zhao,Liangcheng Du,et al. Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818[J]. Molecules,2017,22:1547-1555. |
| APA | Wei Zhang,Baobing Zhao,Liangcheng Du,&Yuemao Shen.(2017).Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.Molecules,22,1547-1555. |
| MLA | Wei Zhang,et al."Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818".Molecules 22(2017):1547-1555. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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