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Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity

文献类型：期刊论文

作者Zhang, Xuejiao1; Lei, Lei1,5; Zhang, Haiyan2; Zhang, Siyu1,4; Xing, Weiwei3; Wang, Jin3; Li, Haibo2,4; Zhao, Qing1; Xing, Baoshan4
刊名ENVIRONMENTAL POLLUTION
出版日期2018-10-01
卷号241页码:701-709
ISSN号0269-7491
关键词Polymeric Nanomicelles Organic Pollutants Partitioning Behavior Combined Cytotoxicity Biointerfacial Behavior
DOI10.1016/j.envpol.2018.06.010
英文摘要Attention has been paid to the environmental distribution and fate of nanomedicines. However, their effects on the toxicity of environmental pollutants are lack of knowledge. In this study, the negatively charged poly (ethylene glycol)-b-poly (L-lactide-co-glycolide) (mPEG-PLA) and positively charged polyethyleneimine-palmitate (PEI-PA) nanomicelles were synthesized and served as model drug carriers to study the interaction and combined toxicity with dichlorodiphenyltrichloroethane (DDT). DDT exerted limited effect on the biointerfacial behavior of mPEG-PLA nanomicelles, whereas it significantly mitigated the attachment of PEI-PA nanomicelles on the model cell membrane as monitored by quartz crystal microbalance with dissipation (QCM-D). The cytotoxicity of DDT towards NIH 3T3 cells was greatly decreased by either co-treatment or pre-treatment with the nanomicelles according to the results of real-time cell analysis (RICA). The cell viability of NIH 3T3 exposed to DDT was increased up to 90% by the co-treatment with mPEG-PLA nanomicelles. Three possible reasons were proposed: (1) decreased amount of free DDT in the cell culture medium due to the partitioning of DDT into nanomicelles; (2) mitigated cellular uptake of nanomicelle-DDT complexes due to the complex agglomeration or electrostatic repulsion between complexes and cell membrane; (3) detoxification effect in the lysosome upon endocytosis of nanomicelle-DDT complexes. (C) 2018 Elsevier Ltd. All rights reserved.
WOS研究方向Environmental Sciences & Ecology
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000440390800075
源URL[http://210.72.129.5/handle/321005/106433]  
专题沈阳应用生态研究所_沈阳应用生态研究所_期刊论文
通讯作者Zhao, Qing
作者单位1.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang, Liaoning, Peoples R China
2.Northeastern Univ, Sch Resources & Civil Engn, Shenyang 110004, Liaoning, Peoples R China
3.Liaoning Beifang Environm Technol Co LTD, Shenyang 110161, Liaoning, Peoples R China
4.Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA
5.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xuejiao,Lei, Lei,Zhang, Haiyan,et al. Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity[J]. ENVIRONMENTAL POLLUTION,2018,241:701-709.
APA Zhang, Xuejiao.,Lei, Lei.,Zhang, Haiyan.,Zhang, Siyu.,Xing, Weiwei.,...&Xing, Baoshan.(2018).Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity.ENVIRONMENTAL POLLUTION,241,701-709.
MLA Zhang, Xuejiao,et al."Interactions of polymeric drug carriers with DDT reduce their combined cytotoxicity".ENVIRONMENTAL POLLUTION 241(2018):701-709.

入库方式： OAI收割

来源：沈阳应用生态研究所

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