中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice

文献类型:期刊论文

作者Zhu, Lin1; Chi, Tianyan1; Zhao, Xuemei1; Yang, Lei1; Song, Shijie1; Lu, Qiaohui1; Ji, Xuefei1; Liu, Peng1; Wang, Lihua2; Zou, Libo1
刊名JOURNAL OF PHYSIOLOGICAL SCIENCES
出版日期2018-09-01
卷号68期号:5页码:555-565
ISSN号1880-6546
关键词Alzheimer's Disease Xanthoceraside Neurogenesis Learning And Memory Wnt/beta-catenin Pathway
DOI10.1007/s12576-017-0561-9
英文摘要Neuronal loss is reported to be an important pathological process in Alzheimer's disease (AD). Neurogenesis is a process of generation of new neurons to fill the neuronal loss. Xanthoceraside has been shown to attenuate the cognitive deficits in several AD animal models. However, little is known about the effect of xanthoceraside on neurogenesis in APP/PS1 transgenic mice. Thus, in this study, we investigated whether xanthoceraside can ameliorate learning and memory impairment by promoting NSCs proliferation and neuronal differentiation. The results suggested that xanthoceraside significantly ameliorated the cognitive impairment and induced NSCs proliferation and neuronal differentiation in APP/PS1 transgenic mice. Meanwhile, in vitro study revealed that xanthoceraside increased the size of NSCs and induced NSCs differentiation into neurons compared with amyloid beta-peptide (25-35) (A beta(25-35)) treatment. Furthermore, we found that xanthoceraside significantly increased the expression of Wnt3a and p-GSK3 beta, decreased the expression of p-beta-catenin, and induced nuclear translocation of beta-catenin in APP/PS1 transgenic mice. Furthermore, in vitro study found that the effect of xanthoceraside on inducing NSCs proliferation and neuronal differentiation were inhibited by Wnt pathway inhibitor Dickkopf-1 (Dkk-1). Our data demonstrated that xanthoceraside may promote the proliferation and differentiation of NSCs into neurons by up-regulating the Wnt/beta-catenin pathway to fill the neuronal loss, thereby improving learning and memory impairment in APP/PS1 transgenic mice.
WOS研究方向Physiology
语种英语
出版者SPRINGER JAPAN KK
WOS记录号WOS:000440613200003
源URL[http://210.72.129.5/handle/321005/106437]  
专题沈阳应用生态研究所_沈阳应用生态研究所_期刊论文
通讯作者Zou, Libo
作者单位1.Shenyang Pharmaceut Univ, Dept Pharmacol, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
2.Chinese Acad Sci, Shenyang Inst Appl Ecol, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Lin,Chi, Tianyan,Zhao, Xuemei,et al. Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice[J]. JOURNAL OF PHYSIOLOGICAL SCIENCES,2018,68(5):555-565.
APA Zhu, Lin.,Chi, Tianyan.,Zhao, Xuemei.,Yang, Lei.,Song, Shijie.,...&Zou, Libo.(2018).Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice.JOURNAL OF PHYSIOLOGICAL SCIENCES,68(5),555-565.
MLA Zhu, Lin,et al."Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice".JOURNAL OF PHYSIOLOGICAL SCIENCES 68.5(2018):555-565.

入库方式: OAI收割

来源:沈阳应用生态研究所

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