Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice
文献类型：期刊论文
| 作者 | Sun, Xiaoyun; Mi, Lixin; Liu, Jin; Song, Lirong; Chung, Fung-Lung; Gan, Nanqin; Song, LR (reprint author), CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Nanlu 7, Wuhan 430072, Peoples R China; lrsong@ihb.ac.cn; gannq@ihb.ac.cn |
| 刊名 | TOXICOLOGY AND APPLIED PHARMACOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 255期号:1页码:9-17 |
| 关键词 | Microcystin-lr (Mc-lr) Sulforaphane (Sfn) Nf-e2-related Factor 2 (Nrf2) Apoptosis Reactive Oxygen Species (Ros) |
| ISSN号 | 0041-008X |
| 英文摘要 | Microcystins (MCs), the products of blooming algae Microcystis, are waterborne environmental toxins that have been implicated in the development of liver cancer, necrosis, and even fatal intrahepatic bleeding. Alternative protective approaches in addition to complete removal of MCs in drinking water are urgently needed. In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells. The purpose of this study was to investigate and confirm efficacy the SFN-induced multi-mechanistic defense system against MC-induced hepatotoxicity in an animal model. We report that SFN protected against MC-LR-induced liver damage and animal death at a nontoxic and physiologically relevant dose in BALB/c mice. The protection by SFN included activities of anti-cytochrome P450 induction, anti-oxidation, anti-inflammation, and anti-apoptosis. Our results suggest that SFN may protect mice against MC-induced hepatotoxicity. This raises the possibility of a similar protective effect in human populations, particularly in developing countries where freshwaters are polluted by blooming algae. (C) 2011 Elsevier Inc. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000293764700002 |
| 资助机构 | 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] |
| 公开日期 | 2011-11-09 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/16371]  |
| 专题 | 水生生物研究所_藻类生物学及应用研究中心_期刊论文 |
| 通讯作者 | Song, LR (reprint author), CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Nanlu 7, Wuhan 430072, Peoples R China; lrsong@ihb.ac.cn; gannq@ihb.ac.cn |
| 推荐引用方式 GB/T 7714 | Sun, Xiaoyun,Mi, Lixin,Liu, Jin,et al. Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2011,255(1):9-17. |
| APA | Sun, Xiaoyun.,Mi, Lixin.,Liu, Jin.,Song, Lirong.,Chung, Fung-Lung.,...&gannq@ihb.ac.cn.(2011).Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.TOXICOLOGY AND APPLIED PHARMACOLOGY,255(1),9-17. |
| MLA | Sun, Xiaoyun,et al."Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice".TOXICOLOGY AND APPLIED PHARMACOLOGY 255.1(2011):9-17. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。