Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China
文献类型：期刊论文
| 作者 | Yang, Fangxing; Jin, Shiwei; Xu, Ying; Lu, Yuanan; Yang, FX (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310003, Zhejiang, Peoples R China; fxyang@ihb.ac.cn; ylu@hawaii.edu |
| 刊名 | ENVIRONMENTAL RESEARCH LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:2页码:24013 |
| 关键词 | Il-8 Ros P53 Pm2.5 A549 Cells E-waste |
| ISSN号 | 1748-9326 |
| 英文摘要 | To identify the different effects of organic-soluble and water-soluble pollutants adsorbed on PM2.5 (PM: particulate matter) released from e-waste (electrical/electronic waste) on inflammatory response, oxidative stress and DNA damage, interleukin-8 (IL-8), reactive oxygen species (ROS) and p53 protein levels were determined and compared in human lung epithelial A549 cells exposed to extracts of PM2.5 collected from two sampling sites in an e-waste recycling area in China. It is found that both extracts induced increases of IL-8 release, ROS production and p53 protein expression. The differences between the organic-soluble and water-soluble extracts were determined as of significance for ROS production (p < 0.05) and p53 protein expression (p < 0.01). The ROS production and p53 protein expression induced by the organic-soluble extracts were found to be greater than those induced by the water-soluble extracts, for both sampling sites. The results indicated that PM2.5 collected from the e-waste recycling areas could lead to inflammatory response, oxidative stress and DNA damage, and the organic-soluble extracts had higher potential to induce such adverse effects on human health. |
| 学科主题 | Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000295326800013 |
| 资助机构 | National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] ; National Natural Science Foundation of China; 863 Research Project[20890113, 2009AA06Z407, 20607030]; Wildlife Trust International; University of Hawaii National Science Foundation[0549514] |
| 公开日期 | 2011-12-22 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/16459]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 通讯作者 | Yang, FX (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, Hangzhou 310003, Zhejiang, Peoples R China; fxyang@ihb.ac.cn; ylu@hawaii.edu |
| 推荐引用方式 GB/T 7714 | Yang, Fangxing,Jin, Shiwei,Xu, Ying,et al. Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China[J]. ENVIRONMENTAL RESEARCH LETTERS,2011,6(2):24013. |
| APA | Yang, Fangxing.,Jin, Shiwei.,Xu, Ying.,Lu, Yuanan.,Yang, FX .,...&ylu@hawaii.edu.(2011).Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China.ENVIRONMENTAL RESEARCH LETTERS,6(2),24013. |
| MLA | Yang, Fangxing,et al."Comparisons of IL-8, ROS and p53 responses in human lung epithelial cells exposed to two extracts of PM2.5 collected from an e-waste recycling area, China".ENVIRONMENTAL RESEARCH LETTERS 6.2(2011):24013. |
入库方式： OAI收割
来源：水生生物研究所
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