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A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years

文献类型：期刊论文

作者Moorjani, Priya1,2; Sankararaman, Sriram3,4,5; Fu, Qiaomei3,6; Przeworski, Molly1,7; Patterson, Nick2; Reich, David2,3,8
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2016-05-17
卷号113期号:20页码:5652-5657
关键词Molecular Clock Generation Interval Ancient Dna Branch Shortening
DOI10.1073/pnas.1514696113
文献子类Article
英文摘要The study of human evolution has been revolutionized by inferences from ancient DNA analyses. Key to these studies is the reliable estimation of the age of ancient specimens. High-resolution age estimates can often be obtained using radiocarbon dating, and, while precise and powerful, this method has some biases, making it of interest to directly use genetic data to infer a date for samples that have been sequenced. Here, we report a genetic method that uses the recombination clock. The idea is that an ancient genome has evolved less than the genomes of present-day individuals and thus has experienced fewer recombination events since the common ancestor. To implement this idea, we take advantage of the insight that all non-Africans have a common heritage of Neanderthal gene flow into their ancestors. Thus, we can estimate the date since Neanderthal admixture for present-day and ancient samples simultaneously and use the difference as a direct estimate of the ancient specimen's age. We apply our method to date five Upper Paleolithic Eurasian genomes with radiocarbon dates between 12,000 and 45,000 y ago and show an excellent correlation of the genetic and C-14 dates. By considering the slope of the correlation between the genetic dates, which are in units of generations, and the C-14 dates, which are in units of years, we infer that the mean generation interval in humans over this period has been 26-30 y. Extensions of this methodology that use older shared events may be applicable for dating beyond the radiocarbon frontier.
WOS关键词NEANDERTHAL ANCESTRY ; HUMAN-POPULATIONS ; RECOMBINATION ; ADMIXTURE ; SEQUENCE ; LANDSCAPE ; LINEAGES ; HOTSPOTS ; HISTORY ; MAP
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000375977600052
资助机构National Institutes of Health (NIH) under Ruth L. Kirschstein National Research Service Award(F32 GM115006-01) ; NIH(5K99GM111744-02 ; National Natural Science Foundation of China(L1524016) ; Chinese Academy of Sciences Discipline Development Strategy Project(2015-DX-C-03) ; US National Institutes of Health(R01 GM83098 ; US National Science Foundation HOMINID Grant(BCS-1032255) ; 4R00GM111744-03) ; GM100233)
源URL[http://124.16.247.212/handle/311034/7086]  
专题古脊椎动物与古人类研究所_图书馆1
作者单位1.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
2.Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA
3.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
4.Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90095 USA
5.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA
6.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China
7.Columbia Univ, Dept Syst Biol, New York, NY 10027 USA
8.Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
推荐引用方式
GB/T 7714		 Moorjani, Priya,Sankararaman, Sriram,Fu, Qiaomei,et al. A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(20):5652-5657.
APA Moorjani, Priya,Sankararaman, Sriram,Fu, Qiaomei,Przeworski, Molly,Patterson, Nick,&Reich, David.(2016).A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(20),5652-5657.
MLA Moorjani, Priya,et al."A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.20(2016):5652-5657.

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