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Genome sequence of a 45,000-year-old modern human from western Siberia
文献类型：期刊论文
| 作者 | Fu, Qiaomei1,2; Li, Heng3,4; Moorjani, Priya3,5; Jay, Flora6; Slepchenko, Sergey M.7; Bondarev, Aleksei A.8; Johnson, Philip L. F.9; Aximu-Petri, Ayinuer2; Pruefer, Kay2; de Filippo, Cesare2 |
| 刊名 | NATURE
 |
| 出版日期 | 2014-10-23 |
| 卷号 | 514期号:7523页码:445-+ |
| DOI | 10.1038/nature13810 |
| 文献子类 | Article |
| 英文摘要 | We present the high-quality genome sequence of a similar to 45,000-year-old modern human male from Siberia. This individual derives from a population that lived before-or simultaneously with-the separation of the populations in western and eastern Eurasia and carries a similar amount of Neanderthal ancestry as present-day Eurasians. However, the genomic segments of Neanderthal ancestry are substantially longer than those observed in present-day individuals, indicating that Neanderthal gene flow into the ancestors of this individual occurred 7,000-13,000 years before he lived. We estimate an autosomal mutation rate of 0.4 x 10(-9) to 0.6 x 10(-9) per site per year, a Y chromosomal mutation rate of 0.7 x 10(-9) to 0.9 x 10(-9) per site per year based on the additional substitutions that have occurred in present-day non-Africans compared to this genome, and a mitochondrial mutation rate of 1.8 x 10(-8) to 3.2 x 10(-8) per site per year based on the age of the bone. |
| WOS关键词 | HUMAN-EVOLUTION ; HUMAN DISPERSALS ; HISTORY ; ASIA ; DIVERGENCE ; ADMIXTURE ; EUROPE |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000343775900030 |
| 源URL | [http://124.16.247.212/handle/311034/7377]  |
| 专题 | 古脊椎动物与古人类研究所_图书馆1 |
| 作者单位 | 1.Chinese Acad Sci, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 2.Max Planck Inst Evolutionare Anthropol, Dept EvolutionaryGenet, D-04103 Leipzig, Germany 3.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 4.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 5.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA 6.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 7.Russian Acad Sci, Siberian Branch, Inst Problems Dev North, Tyumen 625026, Russia 8.Minist Internal Affairs, Omsk Div, Expert Criminalist Ctr, Omsk 644007, Russia 9.Emory Univ, Dept Biol, Atlanta, GA 30322 USA 10.Max Planck Inst Evolutionare Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany |
| 推荐引用方式 GB/T 7714 | Fu, Qiaomei,Li, Heng,Moorjani, Priya,et al. Genome sequence of a 45,000-year-old modern human from western Siberia[J]. NATURE,2014,514(7523):445-+. |
| APA | Fu, Qiaomei.,Li, Heng.,Moorjani, Priya.,Jay, Flora.,Slepchenko, Sergey M..,...&Paeaebo, Svante.(2014).Genome sequence of a 45,000-year-old modern human from western Siberia.NATURE,514(7523),445-+. |
| MLA | Fu, Qiaomei,et al."Genome sequence of a 45,000-year-old modern human from western Siberia".NATURE 514.7523(2014):445-+. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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