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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
文献类型：期刊论文
| 作者 | Mallick, Swapan1,2,3; Li, Heng2; Lipson, Mark1; Mathieson, Iain1; Gymrek, Melissa2,4,5,6; Racimo, Fernando7; Zhao, Mengyao1,2,3; Chennagiri, Niru1,2,3; Nordenfelt, Susanne1,2,3; Tandon, Arti1,2 |
| 刊名 | NATURE
 |
| 出版日期 | 2016-10-13 |
| 卷号 | 538期号:7624页码:201-+ |
| DOI | 10.1038/nature18964 |
| 文献子类 | Article |
| 英文摘要 | Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans. |
| WOS关键词 | MODERN HUMANS ; MUTATION-RATE ; HISTORY ; NEANDERTHAL ; ANCESTRY ; SEQUENCE ; AFRICA ; DISPERSAL ; ADMIXTURE ; INFERENCE |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000386671000037 |
| 资助机构 | Simons Foundation(SFARI 280376) ; US National Science Foundation(BCS-1032255) ; Human Frontier Science program(LT001095/2014) ; Wenner-Gren foundation ; Swedish Research Council (VR)(2014-453) ; NIJ(2014-DN-BX-K089) ; Career Award at the Scientific Interface from the Burroughs Wellcome Fund ; Natural Sciences and Engineering Research Council of Canada ; ERC(FP7- 261213) ; Russian Foundation for Basic Research(15-04-02543 ; Russian Scientific Fund(14-04-00827) ; Estonian Research Council ; European Regional Development Fund (European Union) through the Centre of Excellence in Genomics to Estonian Biocentre ; University of Tartu ; Spanish MINECO(CGL-44351-P) ; NIH(GM59290 ; Wellcome Trust(093051) ; NSF(0924726 ; CSIR Network Project grant(GENESIS: BSC0121) ; Packard Fellowship for Science and Engineering ; Max Planck Society ; 16-34-00599 ; 5DPIES022577 05 ; 1153911) ; 11-04-00725-a ; 1R01DK104339-01 ; 16-06-00303 ; 1R01GM113657-01 ; 16-04-00890) ; R01-GM094402 ; GM100233) |
| 源URL | [http://124.16.247.212/handle/311034/7539]  |
| 专题 | 古脊椎动物与古人类研究所_图书馆1 |
| 作者单位 | 1.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA 2.Broad Inst Harvard & MIT, Cambridge, MA 02142 USA 3.Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA 4.Whitehead Inst Biomed Res, Cambridge, MA 02142 USA 5.MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA USA 6.New York Genome Ctr, New York, NY 10013 USA 7.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 8.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins Chinese, IVPP, Beijing 100044, Peoples R China 9.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 10.Columbia Univ, Dept Comp Sci, New York, NY 10027 USA |
| 推荐引用方式 GB/T 7714 | Mallick, Swapan,Li, Heng,Lipson, Mark,et al. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations[J]. NATURE,2016,538(7624):201-+. |
| APA | Mallick, Swapan.,Li, Heng.,Lipson, Mark.,Mathieson, Iain.,Gymrek, Melissa.,...&Reich, David.(2016).The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.NATURE,538(7624),201-+. |
| MLA | Mallick, Swapan,et al."The Simons Genome Diversity Project: 300 genomes from 142 diverse populations".NATURE 538.7624(2016):201-+. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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