中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Simulation of antisolvent crystallization in impinging jets with coupled multiphase flow-micromixing-PBE

文献类型:期刊论文

作者Cheng, Jingcai1; Yang, Chao1,2; Jiang, Mo3; Li, Qian1,2; Mao, Zai-Sha1
刊名CHEMICAL ENGINEERING SCIENCE
出版日期2017-11-02
卷号171期号:NOV页码:500-512
关键词Antisolvent Crystallization High-resolution Finite-volume Scheme Population Balance Equation Micromixing Openfoam
ISSN号0009-2509
DOI10.1016/j.ces.2017.06.011
文献子类Article
英文摘要

The KT (Kurganov and Tadmor, 2000) finite-volume central scheme is one of the most promising high resolution numerical methods to solve the widely-used population balance equation (PBE) in crystallization and other areas. To meet the practical purpose of geometric-type particle size grid, the primary KT scheme was extended to a general form and validated for pure growth in homogeneous systems. Based on the extended KT scheme, a solver was developed that couples the general discretized PBE and ami-cromixing and a CFD mixture model in OpenFOAM (open-source field operation and manipulation). The simulation uses published parameters from and is compared to experimental antisolvent crystallization of lovastatin from a methanol-water mixture in an impinging jet. The effect of the existing solid crystals on some crystal properties is investigated in this work for the first time. The shapes of crystal size distribution (CSD) at various jet velocities are consistent with experimental observations. The geometric particle size partition is shown to be capable of improving the accuracy of simulation in divisions of the highest particle number densities or steep gradients in the number density. The existing solid crystals are also shown to have a non-negligible effect on the slurry flow crystallization systems once the mean crystal size reaches 20 mu m. (C) 2017 Elsevier Ltd. All rights reserved.

WOS关键词POPULATION BALANCE-EQUATIONS ; COMPUTATIONAL FLUID-DYNAMICS ; SCALE-UP ; CONTINUOUS PRECIPITATION ; CRYSTAL-GROWTH ; BARIUM-SULFATE ; STIRRED-TANK ; AGGREGATION ; NUCLEATION ; BREAKAGE
WOS研究方向Engineering
语种英语
WOS记录号WOS:000409285000042
资助机构National Natural Science Foundation of China(21476236 ; National Key Research and Development Program(2016YFB0301702) ; CAS(QYZDJ-SSW-JSC030) ; Jiangsu National Synergetic Innovation Center for Advanced Materials ; Li Foundation Inc., USA ; 91434126)
源URL[http://ir.ipe.ac.cn/handle/122111/23205]  
专题过程工程研究所_湿法冶金清洁生产技术国家工程实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.MIT, Dept Chem Engn, Cambridge, MA 02139 USA
推荐引用方式
GB/T 7714
Cheng, Jingcai,Yang, Chao,Jiang, Mo,et al. Simulation of antisolvent crystallization in impinging jets with coupled multiphase flow-micromixing-PBE[J]. CHEMICAL ENGINEERING SCIENCE,2017,171(NOV):500-512.
APA Cheng, Jingcai,Yang, Chao,Jiang, Mo,Li, Qian,&Mao, Zai-Sha.(2017).Simulation of antisolvent crystallization in impinging jets with coupled multiphase flow-micromixing-PBE.CHEMICAL ENGINEERING SCIENCE,171(NOV),500-512.
MLA Cheng, Jingcai,et al."Simulation of antisolvent crystallization in impinging jets with coupled multiphase flow-micromixing-PBE".CHEMICAL ENGINEERING SCIENCE 171.NOV(2017):500-512.

入库方式: OAI收割

来源:过程工程研究所

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