A colorimetric fluorescent probe with fluorescence emission feature sensitive to SO2 derivatives, i.e. bisulfite (HSO3 (-)) and sulfite (SO3 (2-)), was developed based on the HSO3 (-)/SO3 (2-)-mediated nucleophilic addition reaction of the probe that. This probe exhibited SO3 (2-) sensing ability with detection limit down to 46 nM and desired selectivity over other reference anions and redox species. The preliminary fluorescence bioimaging experiments have validated the practicability of the as-prepared probe for SO2 derivatives sensing in living cells.