Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes
文献类型：期刊论文
| 作者 | Zhang, Yue1,2; Yu, Xiao-lin2; Zha, Jun2; Mao, Li-zhen3; Chai, Jia-qian1; Liu, Rui-tian2 |
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2018 |
| 卷号 | 192期号:00页码:68-74 |
| 关键词 | Type 2 Diabetes Islet Inflammation Il-1 Beta Therapeutic Vaccine |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/j.lfs.2017.11.021 |
| 文献子类 | Article |
| 英文摘要 | Aims: Inflammation is strongly associated with the mechanism of beta-cell failure in type 2 diabetes mellitus (T2DM). Blockade of the key proinflammatory cytokine IL-1 beta has been implicated as a promising therapeutic strategy for the prevention and treatment of type 2 diabetes. In this study, we developed an IL-1 beta-targeted therapeutic vaccine consisting of an IL-1 beta epitope peptide (A1 beta) and assessed its efficacy on a diabetic KK-A(y) mouse model. |
| WOS关键词 | Nlrp3 Inflammasome ; Islet Dysfunction ; Mellitus ; Interleukin-1-beta ; Canakinumab ; Antagonist ; Activation ; Management ; Inhibitors ; Antibody |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000418477800010 |
| 资助机构 | National Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-005 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040215) ; Natural Science Foundation of Jiangsu Province of China(BK20140245) ; 81402837) ; 2014ZX09102041-007) |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/23470]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 通讯作者 | Chai, Jia-qian; Liu, Rui-tian |
| 作者单位 | 1.Shandong Agr Univ, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, 61 Daizong St, Tai An 271018, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Asialand Biomed Technol Co Ltd, Changzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yue,Yu, Xiao-lin,Zha, Jun,et al. Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes[J]. LIFE SCIENCES,2018,192(00):68-74. |
| APA | Zhang, Yue,Yu, Xiao-lin,Zha, Jun,Mao, Li-zhen,Chai, Jia-qian,&Liu, Rui-tian.(2018).Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes.LIFE SCIENCES,192(00),68-74. |
| MLA | Zhang, Yue,et al."Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes".LIFE SCIENCES 192.00(2018):68-74. |
入库方式： OAI收割
来源：过程工程研究所
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