The hydrodynamics of the binary mixture system in the multisolid pneumatic transport bed (MPTB), where a fine-particle laden gas flows through a coarse particle bed, was investigated by computational fluid dynamics (CFD) simulation. A pseudo-homogeneous method, which considers the gas phase and the fine particle phase as one pseudo-homogeneous dilute phase, was proposed to predict the coarse particle terminal velocity. In the second approach, the fine particle and coarse particle are treated separately, with the structure-based drag model developed in our previous study being used to simulate the coarse particle terminal velocity and fine particle holdup in the coarse particle bed. The simulation results of the two methods showed reasonable agreement with the experimental data under different operating conditions. As observed in the experiment, the terminal velocity of coarse particles decreases with increasing the fine particle flow rate, and the reduction is more significant for larger coarse particles. Besides, the fine particle holdup increases with the decrease of the diameter of coarse particles. These results demonstrated that the multisolid pneumatic transport system can serve as a simple binary system, with its coarse particle terminal velocity and fine particle holdup being used for the verification and validation of binary-particle CFB models. (C) 2017 Elsevier B.V. All rights reserved.