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Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers

文献类型：期刊论文

作者Zhang, Yue1,2; Yu, Xiao-lin1; Zhu, Jie1; Liu, Shu-ying1; Liu, Xiang-meng1; Dong, Quan-xiu1; Chai, Jia-qian2; Liu, Rui-tian1
刊名INTERNATIONAL IMMUNOPHARMACOLOGY
出版日期2018
卷号54页码:145-152
关键词Type 2 Diabetes Mellitus Intravenous Immunoglobulin Islet Amyloid Polypeptide Islet Inflammation Toxic Oligomer
ISSN号1567-5769
DOI10.1016/j.intimp.2017.11.012
文献子类Article
英文摘要Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by beta-cell loss, insulin resistance, islet inflammation and amyloid deposits derived from islet amyloid polypeptide (IAPP). Reducing toxic IAPP oligomers and inhibiting islet inflammation may provide therapeutic benefit in treating T2DM. Intravenous immunoglobulin (IVIg) is an efficient anti-inflammatory and immunomodulatory agent for the treatment of several autoinunune or inflammatory neurological diseases. However, whether Wig has therapeutic potential on T2DM remains unclear. In present study, we showed that IVIg treatment significantly improved glucose control and insulin sensitivity, and prevented-cell apoptosis by lowering toxic IAPP oligomer levels, attenuating islet inflammation and activating autophagy in human IAPP transgenic mouse model. These results suggest that IVIg is a promising therapeutic potential for T2DM treatment.
WOS关键词DIABETES-MELLITUS ; TARGETING INFLAMMATION ; INSULIN-RESISTANCE ; HUMAN-DISEASE ; KAPPA-B ; TOXICITY ; ACTIVATION ; MECHANISM ; ALZHEIMERS ; MANAGEMENT
WOS研究方向Immunology ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000423887900019
资助机构National Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-005 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040215) ; 81402837) ; 2014ZX09102041-007)
源URL[http://ir.ipe.ac.cn/handle/122111/24094]  
专题过程工程研究所_生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Shandong Agr Univ, Tai An 271018, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yue,Yu, Xiao-lin,Zhu, Jie,et al. Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2018,54:145-152.
APA Zhang, Yue.,Yu, Xiao-lin.,Zhu, Jie.,Liu, Shu-ying.,Liu, Xiang-meng.,...&Liu, Rui-tian.(2018).Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers.INTERNATIONAL IMMUNOPHARMACOLOGY,54,145-152.
MLA Zhang, Yue,et al."Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers".INTERNATIONAL IMMUNOPHARMACOLOGY 54(2018):145-152.

入库方式： OAI收割

来源：过程工程研究所

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