Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan
文献类型：期刊论文
| 作者 | Zhang, Guiqiang1,2,3; Liu, Jing2,3,4; Li, Ruilian1,2,3; Jiao, Siming2,3; Feng, Cui2,3; Wang, Zhuo A.2,3; Du, Yuguang1,2,3 |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 16期号:5页码:13 |
| 关键词 | Staphylococcus aureus biofilm chitosan conjugation inulin |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md16050151 |
| 英文摘要 | Bacteria biofilm helps bacteria prevent phagocytosis during infection and increase resistance to antibiotics. Staphylococcus aureus is a Gram-positive pathogenic bacterium and is tightly associated with biofilm-related infections, which have led to great threat to human health. Chitosan, the only cationic polysaccharide in nature, has been demonstrated to have antimicrobial and anti-biofilm activities, which, however, require a relative high dosage of chitosan. Moreover, poor water solubility further restricts its applications on anti-infection therapy. Inulins are a group of polysaccharides produced by many types of plants, and are widely used in processed foods. Compared to chitosan, inulin is very soluble in water and possesses a mild antibacterial activity against certain pathogenic bacteria. In order to develop an effective strategy to treat biofilm-related infections, we introduce a method by covalent conjugation of inulin to chitosan. The physicochemical characterization of the inulin-chitosan conjugate was assayed, and the anti-biofilm activity was evaluated against S. aureus biofilm. The results indicated that, as compared to chitosan, this novel polysaccharide-polysaccharide conjugate significantly enhanced activities against S. aureus either in a biofilm or planktonic state. Of note, the conjugate also showed a broad spectrum anti-biofilm activity on different bacteria strains and low cellular toxicity to mammalian cells. These results suggested that chitosan conjugation of inulin was a viable strategy for treatment against biofilm-related infections. This finding may further spread the application of natural polysaccharides on treatments of infectious disease. |
| WOS关键词 | INFECTIONS ; DERIVATIVES ; CHITIN ; AGENT ; MODE ; MICE |
| 资助项目 | National Natural Science Fund, China[31670809] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000435195100014 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Fund, China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/25030]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 通讯作者 | Wang, Zhuo A.; Du, Yuguang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Northwest A&F Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Guiqiang,Liu, Jing,Li, Ruilian,et al. Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan[J]. MARINE DRUGS,2018,16(5):13. |
| APA | Zhang, Guiqiang.,Liu, Jing.,Li, Ruilian.,Jiao, Siming.,Feng, Cui.,...&Du, Yuguang.(2018).Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan.MARINE DRUGS,16(5),13. |
| MLA | Zhang, Guiqiang,et al."Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan".MARINE DRUGS 16.5(2018):13. |
入库方式： OAI收割
来源：过程工程研究所
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