For a large-aperture space telescope, one of the key techniques is the method for designing the lightweight primary mirror assembly (PMA). In order to minimize the mirror surface error under axial gravity, lateral gravity, and polishing pressure at the same time, a method for topology optimization with multi-objective function combined with parametric optimization is introduced in this paper. The weighted compliance minimum is selected as the objective function to maximum the mirror structural stiffness. Then sensitivity analysis method and size optimization are used to determine the mirror structure parameters. Compared with two types of commonly used lightweight configurations, the new configuration design shows obvious superiority. In addition, the surface figure root mean square (RMS) of the mirror mounted by given bipod flexure (BF) under 1 g lateral gravity is minimized only with a value of 3.58 nm, which proves the effectiveness of the design method proposed in this paper.