Hollow Au-Ag Nanoparticles Labeled Immunochromatography Strip for Highly Sensitive Detection of Clenbuterol
文献类型：期刊论文
| 作者 | Wang, Jingyun; Zhang, Lei; Dai, Liwei; Zhang, Ganggang; Lu, Xuefei; Zhang, Jiawei; Lai, Weihua; Chen, Tao; Huang, Youju; Dandapat, Anirban |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2017 |
| 卷号 | 7页码:41419 |
| ISSN号 | 2045-2322 |
| 英文摘要 | The probe materials play a significant role in improving the detection efficiency and sensitivity of lateral-flow immunochromatographic test strip (ICTS). Unlike conventional ICTS assay usually uses single-component, solid gold nanoparticles as labeled probes, in our present study, a bimetallic, hollow Au-Ag nanoparticles (NPs) labeled ICTS was successfully developed for the detection of clenbuterol (CLE). The hollow Au-Ag NPs with different Au/Ag mole ratio and tunable size were synthesized by varying the volume ratio of [HAuCl4]:[Ag NPs] via the galvanic replacement reaction. The surface of hollow Ag-Au NPs was functionalized with 11-mercaptoundecanoic acid (MUA) for further covalently bonded with anti-CLE monoclonal antibody. Overall size of the Au-Ag NPs, size of the holes within individual NPs and also Au/Ag mole ratio have been systematically optimized to amplify both the visual inspection signals and the quantitative data. The sensitivity of optimized hollow Au-Ag NPs probes has been achieved even as low as 2 ppb in a short time (within 15 min), which is superior over the detection performance of conventional test strip using Au NPs. The optimized hollow Au-Ag NPs labeled test strip can be used as an ideal candidate for the rapid screening of CLE in food samples. |
| 公开日期 | 2017-12-25 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/14024]  |
| 专题 | 2017专题 |
| 推荐引用方式 GB/T 7714 | Wang, Jingyun,Zhang, Lei,Dai, Liwei,et al. Hollow Au-Ag Nanoparticles Labeled Immunochromatography Strip for Highly Sensitive Detection of Clenbuterol[J]. Scientific Reports,2017,7:41419. |
| APA | Wang, Jingyun.,Zhang, Lei.,Dai, Liwei.,Zhang, Ganggang.,Lu, Xuefei.,...&Dandapat, Anirban.(2017).Hollow Au-Ag Nanoparticles Labeled Immunochromatography Strip for Highly Sensitive Detection of Clenbuterol.Scientific Reports,7,41419. |
| MLA | Wang, Jingyun,et al."Hollow Au-Ag Nanoparticles Labeled Immunochromatography Strip for Highly Sensitive Detection of Clenbuterol".Scientific Reports 7(2017):41419. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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