Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness
文献类型：期刊论文
| 作者 | Chen, Xiyi; Yang, Xi; Chen, Qixian; Yang, Jinjun; Wu, Sudong; Liu, Jun; Li, Zhen; Liu, Deqiang; Qiu, Yongming |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:50页码:44045-44052 |
| 关键词 | Polyplex Micelle Cancer-therapy Drug-delivery Nanoparticle Therapeutics Future Size |
| 英文摘要 | With respect to the intriguing biocompatibility and the stealthy functions of poly(ethylene glycol),(PEGE), PEGylated nanopatticulates have- been intensively engineered for utilities as diug delivery vehicles.7o advocate the targeted druorinsportation, targeting ligands were strategically installed onto the surfaCe of PEGylated "nanoparticulates. The previous in vitro investigations revealed that the ligancl-specified cell endocytosis of nanopartictilates was pronounced for the nanoparticulates with adequately high PEG crowdedness. The present study aims to explore insight into the impact of PEGylation degree on in vivo tumor-targeted accumulation activities of cRGD-installed nanoparticulates. The subsequent investigations verified the importance of the PEGylation crowdedness in pursuit of prolonged retention in the blood circulation post intravenous administration. Unprecedettedly, the PEGylation crowdedness was also identified as a crucial important parameter to pursue the tumor-targeted accumulation. A plausible reason is the elevated PEGylation crowdedness eliciting the restricted involvement iri nonspecific protein adsorption of nanoparticulates in the biological milieu and consequently pronouncing the ligand-receptor-mediated binding for the nanoparticulates. Notewoithy was the distinctive performance Of the class of the proposed systems once utilized for transportation of the mRNA payload to the tumors. The protein expression in the targeted tumors appeared to follow a clear PEGylation crowdedness dependence manner, where merely 2-fold PEGylation crowdedness led to remarkably 10-fold augmentation in protein expression in tumors. Hence, the results provided important information and implications for design of active-targeting PEGylated nanomaterials to fulfill the targeting strategies in systemic applications. |
| 学科主题 | Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering |
| 语种 | 英语 |
| 公开日期 | 2018-12-04 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/17486]  |
| 专题 | 2017专题 |
| 推荐引用方式 GB/T 7714 | Chen, Xiyi,Yang, Xi,Chen, Qixian,et al. Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(50):44045-44052. |
| APA | Chen, Xiyi.,Yang, Xi.,Chen, Qixian.,Yang, Jinjun.,Wu, Sudong.,...&Qiu, Yongming.(2017).Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness.ACS APPLIED MATERIALS & INTERFACES,9(50),44045-44052. |
| MLA | Chen, Xiyi,et al."Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness".ACS APPLIED MATERIALS & INTERFACES 9.50(2017):44045-44052. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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