Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy
文献类型：期刊论文
| 作者 | Wang, Hui; Li, Jinglong; Liu, Fu; Li, Tiantian; Zhong, Yun; Lin, Haibo; He, Jidong |
| 刊名 | REACTIVE & FUNCTIONAL POLYMERS
 |
| 出版日期 | 2018 |
| 卷号 | 124页码:104-114 |
| 关键词 | Polyethersulfone Membranes Polylactide Membrane Blood Compatibility Antifouling Properties Polysulfone Membranes Anticoagulant Coatings Polymers Pyrrolidone) Biomaterials |
| 英文摘要 | Insufficient hemocompatibility is challenging for current dialysis membranes. The current modification methods have some limitations in effectiveness, practicality and cost. Herein, we develop a heparin-free crosslinking approach to enhance the hemocompatibility of both the flat (polylactide) and hollow fiber (polysulfone) membranes with heparin -mimicking surface. Poly (triethoxyvinylsilane-N-vinyl-2-pyrrolidone) (P (VTES-VP)) is first introduced to the membrane surface to improve the hydrophilicity, which is facilitated to the adsorption and further crosslinking of poly (triethoxyvinylsilane-Acrylic acid -Sodium 4-vinylbenzenssulfonate) (P(VTESAA-SSNa)). The mixture of N, N-dimethylacetamide (DMAc) and water was modulated for good solubility, swelling and adsorption of precopolymer. The chemical structure of the heparin -mimicking membrane was confirmed by attenuated total reflectance Fourier transform infrared spectra (FTIR-ATR), X-ray photoelectron spectroscopy (XPS), weight measurement and scanning electron microscopy (SEM). The hydrophilicity was improved by the heparin -mimicking surface. Moreover, the heparin -mimicking membranes presents higher platelet resistance, prolonged coagulation time (APTT for similar to 180.1 s), decreased Plasma fibrinogen (FIB for similar to 122 mg/dL), and suppressed complement activation. More importantly, the heparin -free crosslinking approach can be utilized to significantly enhance the hemocompatibility of commercial PSF hollow fiber membranes, indicating its potential application in heparin free dialyzers. |
| 学科主题 | Chemistry ; Engineering ; Polymer Science |
| 语种 | 英语 |
| 公开日期 | 2018-12-04 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/16770]  |
| 专题 | 2018专题 |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Li, Jinglong,Liu, Fu,et al. Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy[J]. REACTIVE & FUNCTIONAL POLYMERS,2018,124:104-114. |
| APA | Wang, Hui.,Li, Jinglong.,Liu, Fu.,Li, Tiantian.,Zhong, Yun.,...&He, Jidong.(2018).Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy.REACTIVE & FUNCTIONAL POLYMERS,124,104-114. |
| MLA | Wang, Hui,et al."Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy".REACTIVE & FUNCTIONAL POLYMERS 124(2018):104-114. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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