Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD
文献类型：期刊论文
| 作者 | Wang, Hui; Shi, Xiao; Gao, Ailin; Lin, Haibo; Chen, Yongliang; Ye, Yumin; He, Jidong; Liu, Fu; Deng, Gang |
| 刊名 | APPLIED SURFACE SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 433页码:869-878 |
| 关键词 | Surface Modification Blood Compatibility Polyethersulfone Membranes Hemodialysis Anticoagulant Biocompatibility Mechanism |
| 英文摘要 | In the present work, we report one-step immobilization of nano-heparin coating on PLA membranes via initiated chemical vapor deposition (iCVD) for enhanced hemocompatibility. The nano-coating introduced onto the membrane surface via the crosslinking of P(MAA-EGDA) was confirmed by the FTIR, SEM and weight measurement respectively. The negative carboxyl groups could form the hydration interaction with the protein and platelets and electrostatic interaction with amide groups of thrombin by the mediation of antithrombin, which is similar but different with heparin. The P(MAA-EGDA) coated membranes showed suppressed platelet adhesion and prolonged clotting time (APTTs increased to 59 s, PTs increased to 20.4 s, TTs increased to 17.5 s, and the FIBs declined by 30 mg/dL). Moreover, the complement activation tests demonstrated the formation of C3a and C5a was inhibited. All results demonstrated that the nano-coating of P(MAA-EGDA) via iCVD significantly enhanced the hemocompatibility of PLA membranes, which is also applicable for various membranes. (C) 2017 Elsevier B.V. All rights reserved. |
| 学科主题 | Chemistry |
| 语种 | 英语 |
| 公开日期 | 2018-12-04 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/16778]  |
| 专题 | 2018专题 |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Shi, Xiao,Gao, Ailin,et al. Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD[J]. APPLIED SURFACE SCIENCE,2018,433:869-878. |
| APA | Wang, Hui.,Shi, Xiao.,Gao, Ailin.,Lin, Haibo.,Chen, Yongliang.,...&Deng, Gang.(2018).Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD.APPLIED SURFACE SCIENCE,433,869-878. |
| MLA | Wang, Hui,et al."Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD".APPLIED SURFACE SCIENCE 433(2018):869-878. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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