Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach
文献类型：期刊论文
| 作者 | Wang, Hui; Hou, Wenjia; Liu, Fu; Han, Qiu; Li, Tiantian; Lin, Haibo; Deng, Gang; He, Jidong |
| 刊名 | JOURNAL OF MEMBRANE SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 563页码:115-125 |
| 关键词 | Polyethersulfone Membranes Antifouling Properties Polylactide Membrane Polymeric Membranes Heparin Hemodialysis Hemocompatibility Anticoagulant Cytocompatibility Conjugation |
| 英文摘要 | It is challenging to improve the hemocompatibility of commercial dialyzers packaging more than 10,000 fibers. Herein, we report the preparation and evaluation of a self-anticlotting Polysulfone dialyzer via an interface crosslinking approach. By modulating the conformation of sulfate, carboxyl groups and pyrrolidone (VP) in heparin-like polymers, the hemocompatibility of the dialyzer was significantly improved. It was found that the sequential structure of functional groups influenced the anticoagulant performances substantially. The hollow fiber modified by the blended polymer (Poly (N-vinyl-2-pyrrolidone-co-triethoxyvinylsilane) and poly (Sodium 4-vinylbenzenssulfonate-co-triethoxyvinylsilane-co-Acrylic acid) (P(VP-VTES)-b-P(SSNa-VTES-AA))) exhibited better hemocompatibility than the contrast membrane modified by poly (Acrylic acid-co-triethoxyvinylsilane-co -N-vinyl-2-pyrrolidone-co--co-Sodium 4-vinylbenzenssulfonate) (P(AA-VTES-VP-SSNa)). The chemical composition was determined by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectra (FTIR). The morphology of the hollow fiber membranes was observed by a scanning electron microscopy (SEM). The thrombin time (TT), plasma fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT) and protein adsorption were measured to examine the hemocompatibility. The modified hollow fiber showed self-anticlotting properties with excellent protein resistance, remarkably prolonged coagulation time (APTT> 600 s), suppressed complement activation and nontoxicity to osteoblasts. The modified dialyzer showed practicable ultrafiltration coefficient and clearance performance, indicating its great potential application in dialysis treatment. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 公开日期 | 2018-12-04 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/17168]  |
| 专题 | 2018专题 |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Hou, Wenjia,Liu, Fu,et al. Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach[J]. JOURNAL OF MEMBRANE SCIENCE,2018,563:115-125. |
| APA | Wang, Hui.,Hou, Wenjia.,Liu, Fu.,Han, Qiu.,Li, Tiantian.,...&He, Jidong.(2018).Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach.JOURNAL OF MEMBRANE SCIENCE,563,115-125. |
| MLA | Wang, Hui,et al."Preparation and evaluation of a self-anticlotting dialyzer via an interface crosslinking approach".JOURNAL OF MEMBRANE SCIENCE 563(2018):115-125. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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