Synthesis, characterization and applications of maghemite beads functionalized with rabbit antibodies
文献类型：期刊论文
| 作者 | Mariuba, L. A.; Chaves, Y. O.; Barbosa, L.; Iqbal, M. Zubair; Faria, F. S. E. D. V.; Morales, M. A.; dos Santos, C. C.; Rocha, C. O.; Piazza, R. D.; Rodriguez, A. F. R. |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 29期号:36 |
| 关键词 | Iron-oxide Nanoparticles Magnetic Nanoparticles Flow-cytometry Bioseparations |
| 英文摘要 | Magnetic nanoparticles (NPs) have attracted great attention owing to their applications in the biomedical field. In the present work, maghemite (gamma Fe2O3) NPs of 6.5 nm were prepared using a sonochemical method and used to prepare magnetic beads through silanization with 3-aminopropyltrimethoxysilane (APTS). Subsequently, amino groups in the resulting APTS-gamma Fe2O3 beads were converted to carboxylic acid (CARB-gamma Fe2O3) through the succinic anhydride reaction, as confirmed by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy and dynamic light scattering (DLS) measurements. The size of these beads was measured as 12 nm and their hydrodynamic diameter as 490 nm, using TEM analysis and DLS, respectively. The CARB-gamma Fe2O3 beads were further functionalized by immobilizing rabbit antibodies on their surfaces; the immobilization was confirmed by flow cytometry and ionic strength. The samples were further characterized by Mossbauer spectroscopy and DC magnetization measurements. Studies on magnetic relaxivities showed that magnetic beads present great potential for application in MR imaging. |
| 学科主题 | Materials Science |
| 语种 | 英语 |
| 公开日期 | 2018-12-04 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/17209]  |
| 专题 | 2018专题 |
| 推荐引用方式 GB/T 7714 | Mariuba, L. A.,Chaves, Y. O.,Barbosa, L.,et al. Synthesis, characterization and applications of maghemite beads functionalized with rabbit antibodies[J]. NANOTECHNOLOGY,2018,29(36). |
| APA | Mariuba, L. A..,Chaves, Y. O..,Barbosa, L..,Iqbal, M. Zubair.,Faria, F. S. E. D. V..,...&Jafelicci, M., Jr..(2018).Synthesis, characterization and applications of maghemite beads functionalized with rabbit antibodies.NANOTECHNOLOGY,29(36). |
| MLA | Mariuba, L. A.,et al."Synthesis, characterization and applications of maghemite beads functionalized with rabbit antibodies".NANOTECHNOLOGY 29.36(2018). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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