Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells
文献类型：期刊论文
| 作者 | Zhang, Lili; Wang, Siqi; Ren, Wenzhi; Wang, Jianhua; Jiang, Zhenqi; Li, Aiguo; Wu, Aiguo; Saeed, Madiha |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:8页码:2209-2218 |
| 关键词 | Imaging Contrast Agent Photodynamic Therapy Breast-cancer Nanoparticles Nanoplatform Metastasis Tio2 Nanocomposites Resistance Titania |
| 英文摘要 | At present, transmembrane glycoprotein CD133 highly expressed pancreatic cancer stem cells (PCSCs), with the features of chemotherapeutic/radiotherapeutic resistance and exclusive tumorigenic potential, are considered as the primary cause of metastasis and recurrence in pancreatic cancer, and therefore are an effective target in the disease treatment. Furthermore, with the launch of precision medicine, multifunctional nanoprobes have been applied as an efficient strategy for the magnetic resonance imaging (MRI)-guided photothermal therapy (PTT) of pancreatic cancer. In this research, with the aim of achieving precise MRI-guided PTT in CD133 highly expressed PCSCs, novel bTiO(2)-Gd-CD133mAb nanoprobes were designed and successfully prepared by loading Gd-DOTA and CD133 monoclonal antibodies on black TiO2 nanoparticles. It was very interesting to find that the r(1) relaxivity value of the nanoprobes was 34.394 mM(-1) s(-1), about 7.5 times that of commercial Magnevist (4.5624 mM(-1) s(-1)), which indicates that the nanoprobes have good potential as MRI T-1 contrast agents with excellent performance. Herein, CD133 highly expressed PANC-1 cells were selected and verified as PCSCs model. In vitro experiments demonstrated that the nanoprobes exhibited active-targeting ability in PANC-1 cells, and consequently could specially enhance T-1-weighted MR imaging and 808 nm near-infrared (NIR)-triggered PTT efficiency in the PCSCs model. Our study not only provides a new strategy for the effective treatment of pancreatic cancer and its' stem cells, but also further broadens the application of black TiO2 in the field of cancer theranostics. |
| 学科主题 | Polymer Science |
| 语种 | 英语 |
| 公开日期 | 2018-12-04 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/17269]  |
| 专题 | 2018专题 |
| 推荐引用方式 GB/T 7714 | Zhang, Lili,Wang, Siqi,Ren, Wenzhi,et al. Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells[J]. BIOMATERIALS SCIENCE,2018,6(8):2209-2218. |
| APA | Zhang, Lili.,Wang, Siqi.,Ren, Wenzhi.,Wang, Jianhua.,Jiang, Zhenqi.,...&Saeed, Madiha.(2018).Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells.BIOMATERIALS SCIENCE,6(8),2209-2218. |
| MLA | Zhang, Lili,et al."Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells".BIOMATERIALS SCIENCE 6.8(2018):2209-2218. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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