In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping
文献类型：期刊论文
| 作者 | Ali, Syed Mansoor; Shaheen, Fozia; Aziz, Muhammad Hammad; Fatima, Mahvish; Khan, Muhammad Ajmal; Ahmed, Faisal; Ahmad, Riaz; Ahmad, Muhammad Ashfaq; Alkhuraiji, Turki S.; Akram, Muhammad Waseem |
| 刊名 | NANOMATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:7 |
| 关键词 | Reduced Graphene Oxide Photothermal Therapy Oxidative Stress Antibacterial Properties Breast-cancer Nanocomposites Toxicity Biocompatibility Nanomaterials Delivery |
| 英文摘要 | Graphene-based materials have attracted considerable interest owing to their distinctive characteristics, such as their biocompatibility in terms of both their physical and intrinsic chemical properties. The use of nanomaterials with graphene as a biocompatible agent has increased due to an uptick in dedication from biomedical investigators. Here, GO-ZnO was characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), ultraviolet-visible (UV-Vis) spectroscopy, energy dispersive X-ray analysis (EDAX), and Raman spectroscopy for structural, morphological, and elemental analysis. The toxic extent of GO-ZnO was noted by a methyl-thiazole-tetrazolium (MTT), while cellular morphology was observed towards the MCF-7 cells using an inverted microscope at magnification 40 x. The cytotoxic effect of GO-ZnO investigated the cell viability reduction in a dose-dependent manner, as well as prompted the cell demise /destruction in an apoptotic way. Moreover, statistical analysis was performed on the experimental outcomes, with p-values < 0.05 kept as significant to elucidate the results. The generation of reactive oxygen species (ROS) demonstrated the potential applicability of graphene in tumor treatment. These key results attest to the efficacy of GO-ZnO nanocomposites as a substantial candidate for breast malignancy treatment. |
| 学科主题 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 公开日期 | 2018-12-04 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/17330]  |
| 专题 | 2018专题 |
| 推荐引用方式 GB/T 7714 | Ali, Syed Mansoor,Shaheen, Fozia,Aziz, Muhammad Hammad,et al. In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping[J]. NANOMATERIALS,2018,8(7). |
| APA | Ali, Syed Mansoor.,Shaheen, Fozia.,Aziz, Muhammad Hammad.,Fatima, Mahvish.,Khan, Muhammad Ajmal.,...&Raza, Rizwan.(2018).In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping.NANOMATERIALS,8(7). |
| MLA | Ali, Syed Mansoor,et al."In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping".NANOMATERIALS 8.7(2018). |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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