Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing
文献类型:期刊论文
作者 | Wang, Yi1; Li, Zhi1,2; Liu, Wen-hua3; Wei, Xin-hua4; Jiang, Xin-qing4; Lui, Simon S. Y.5; So, Suzanne Ho-Wai6; Cheung, Eric F. C.5; Debbane, Martin7,8,9; Chan, Raymond C. K.1,2 |
刊名 | SCHIZOPHRENIA BULLETIN |
出版日期 | 2018-11-01 |
卷号 | 44页码:S491-S500 |
ISSN号 | 0586-7614 |
关键词 | Facial Emotion Discrimination Functional Connectivity Negative Schizotypy Amygdala Mpfc |
DOI | 10.1093/schbul/sby036 |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS), little is known about the corresponding change in brain functional connectivity. Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia. All participants undertook a facial emotion discrimination functional imaging task that consisted of four emotional valences (angry, fear, happy, and neutral). For univariate analysis, the signal change at the bilateral amygdala was compared for each emotional contrast using SPSS (P < .05). For the functional connectivity analysis, we calculated the beta-series functional connectivity of the bilateral amygdala with the medial prefrontal cortex (mPFC) and compared the group differences in SPM12 (P < .05, small volume family-wise error correction). Results: No significant differences were found between the high and low NS groups in accuracy and reaction time in the facial emotion discrimination task. The high NS group showed reduced brain activations at the amygdala under fearful and neutral conditions. Reduced functional connectivity between the amygdala and the mPFC/dorsal anterior cingulate cortex under the happy and fearful conditions in the high NS group was also found. Conclusions: Our findings suggest that the individuals with high NS showed altered brain activity and functional connectivity at the amygdala during facial emotion processing and provide new evidence for understanding social cognition deficits in at-risk individuals. |
WOS关键词 | Clinical High-risk ; Psychosis-proneness ; Affect Recognition ; Social Cognition ; Psychometric Schizotypy ; Organizing Framework ; Brain Structure ; Schizophrenia ; Individuals ; Metaanalysis |
资助项目 | Beijing Municipal Science & Technology Commission[Z161100000216138] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams[Y2CX131003] ; National Science Fund China[31400884] ; China Scholarship Council |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | OXFORD UNIV PRESS |
WOS记录号 | WOS:000448172600005 |
资助机构 | Beijing Municipal Science & Technology Commission ; National Key Research and Development Programme ; Beijing Training Project for Leading Talents in ST ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams ; National Science Fund China ; China Scholarship Council |
源URL | [http://ir.psych.ac.cn/handle/311026/27294] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Wang, Yi |
作者单位 | 1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Guangzhou Med Univ, Fac Hlth Management, Guangzhou, Guangdong, Peoples R China 4.Guangzhou First Peoples Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China 5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 6.Chinese Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China 7.Univ Geneva, Fac Psychol & Educ Sci, Dev Clin Psychol Res Unit, Geneva, Switzerland 8.Univ Geneva, Sch Med, Dev NeuroImaging & Psychopathol Lab, Dept Psychiat, Geneva, Switzerland 9.UCL, Res Dept Clin Educ & Hlth Psychol, London, England |
推荐引用方式 GB/T 7714 | Wang, Yi,Li, Zhi,Liu, Wen-hua,et al. Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing[J]. SCHIZOPHRENIA BULLETIN,2018,44:S491-S500. |
APA | Wang, Yi.,Li, Zhi.,Liu, Wen-hua.,Wei, Xin-hua.,Jiang, Xin-qing.,...&Chan, Raymond C. K..(2018).Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing.SCHIZOPHRENIA BULLETIN,44,S491-S500. |
MLA | Wang, Yi,et al."Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing".SCHIZOPHRENIA BULLETIN 44(2018):S491-S500. |
入库方式: OAI收割
来源:心理研究所
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。