Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals
文献类型:期刊论文
作者 | Ibrahim, Omar1; Sutherland, Heidi G.1; Avgan, Nesli1; Spriggens, Lauren K.2,3; Lea, Rod A.1; Haupt, Larisa M.1; Shum, David H. K.2,3,4; Griffiths, Lyn R.1 |
刊名 | NEUROBIOLOGY OF LEARNING AND MEMORY |
出版日期 | 2018-11-01 |
卷号 | 155页码:330-336 |
ISSN号 | 1074-7427 |
关键词 | Memory Executive functions Information processing speed Genetic polymorphisms Adhesion molecule Neural plasticity CADM2 Stroop test Trail Making Test |
DOI | 10.1016/j.nlm.2018.08.001 |
产权排序 | 3 |
文献子类 | article |
英文摘要 | The common polymorphism rs17518584, near the cell adhesion molecule 2 gene (CADM2), was previously identified as playing a role in information processing speed in a genome-wide association study of executive functions and processing speed performed in a cohort of non-demented older adults. In this study, we investigated this polymorphism in a younger population cohort 30 years old, median age 19 years), with no known memory or psychiatric disorders, for which we had phenotyped all participants for memory function (n = 514), and a subset of the participants for executive functions (n = 338), using a battery of tests measuring visuo-spatial memory, working memory, verbal memory, and frontal lobe functions (visual scanning, graphomotor speed, and cognitive flexibility). The polymorphism rs17518584 was genotyped by a restriction fragment length polymorphism assay and analysis indicated that the CADM2 polymorphism showed evidence of association with information processing speed as inferred from scores from the Stroop Word, Colour, and Colour Word Tests (p = 0.005, p = 0.04, and p = 0.028, respectively, in a dominant inheritance model), as well as Trail Making Test Part A (p = 0.005 in an additive model). Significant associations of rs17518584 with scores from other tests of memory subtypes were not detected. The findings of this study provide further support for a role of CADM2 in aspects of cognitive function, in particular reading and information processing speed, and suggest that this role extends to younger individuals. |
WOS关键词 | GENOME-WIDE ASSOCIATION ; ANTERIOR CINGULATE CORTEX ; WORKING-MEMORY ; PROCESSING SPEED ; GENETIC OVERLAP ; NORMATIVE DATA ; STROOP TEST ; SCHIZOPHRENIA ; METAANALYSIS ; ADHESION |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Psychology |
语种 | 英语 |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS记录号 | WOS:000449310000035 |
源URL | [http://ir.psych.ac.cn/handle/311026/27560] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Griffiths, Lyn R. |
作者单位 | 1.QUT, Sch Biomed Sci, Inst Hlth & Biomed Innovat, Genom Res Ctr, Brisbane, Qld, Australia 2.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia 3.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Ibrahim, Omar,Sutherland, Heidi G.,Avgan, Nesli,et al. Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2018,155:330-336. |
APA | Ibrahim, Omar.,Sutherland, Heidi G..,Avgan, Nesli.,Spriggens, Lauren K..,Lea, Rod A..,...&Griffiths, Lyn R..(2018).Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals.NEUROBIOLOGY OF LEARNING AND MEMORY,155,330-336. |
MLA | Ibrahim, Omar,et al."Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals".NEUROBIOLOGY OF LEARNING AND MEMORY 155(2018):330-336. |
入库方式: OAI收割
来源:心理研究所
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