中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital

文献类型:期刊论文

作者Cao, Zeyuan1; Wu, Shuang2,3; Wang, Chao2,3; Wang, Li4; Soares, Jair C.5; He, Shu-Chang2,3; Zhang, Xiang Yang4,5
刊名PSYCHOPHARMACOLOGY
出版日期2018-11-01
卷号235期号:11页码:3125-3135
关键词Burnout Stress Serotonin Transporter Genotype Association Interaction
ISSN号0033-3158
DOI10.1007/s00213-018-5009-2
产权排序4
文献子类Article
英文摘要

Objective Many studies have reported that long-term exposure to job-related stress can lead to burnout, which may be influenced by genetic and environmental factors. Burnout correlates with depression. This study investigated whether one tag polymorphism rs6354 in 5-HTT gene modulated the influence of job-related stress on burnout in the medical professionals in a Chinese Han population, which to our best knowledge has not been explored. Methods Seven hundred twelve subjects were recruited from a general hospital and measured for burnout symptoms using the Maslach Burnout Inventory (MBI), the stress using the House and Rizzo's Work Stress Scale, and the stressors using the Evers, Frese, and Cooper's Sources of Pressure Scale. The 5-HTT rs6354 polymorphism was genotyped in 376 subjects. Results The majority of correlations between the work stress score or the six stressor scores and three burnout subscores were significant (all p < 0.05). There was no significant main effect of the 5-HTT rs6354 genotype on burnout symptoms; however, there was a statistically significant interaction between 5-HTT rs6354 and work stress on burnout (F = 5.08, df = 2, 369, p = 0.007). In the low stress group, G allele carriers had significantly higher burnout level than TT homozygote (F = 11.60, df = 1, 48, p < 0.001). On the contrary, in the high stress group, G allele carriers exhibited significantly lower burnout level compared to TT homozygote (F = 3.86, df = 1, 103, p = 0.025). Conclusions Our findings suggest that the 5-HTT rs6354 polymorphism may modulate the influence of job-related stress on burnout by adjusting serotonin transporter function and neurotransmission, showing that individuals with TT genotype displayed a greater susceptibility to both the detrimental effects of higher stress and the beneficial effects of lower stress compared to those with G allele, which supports the differential-susceptibility hypothesis.

WOS关键词Single-nucleotide Polymorphisms ; Life Events ; Depressive Symptoms ; Association ; Region ; Susceptibility ; Moderation ; Slc6a4 ; Replication ; Disorders
资助项目National Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81371477]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
WOS记录号WOS:000448485500005
出版者SPRINGER
源URL[http://ir.psych.ac.cn/handle/311026/27491]  
专题心理研究所_健康与遗传心理学研究室
通讯作者He, Shu-Chang; Zhang, Xiang Yang
作者单位1.Brandeis Univ, Dept Biochem, Waltham, MA 02254 USA
2.Peking Univ, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China
3.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA
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Cao, Zeyuan,Wu, Shuang,Wang, Chao,et al. Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital[J]. PSYCHOPHARMACOLOGY,2018,235(11):3125-3135.
APA Cao, Zeyuan.,Wu, Shuang.,Wang, Chao.,Wang, Li.,Soares, Jair C..,...&Zhang, Xiang Yang.(2018).Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital.PSYCHOPHARMACOLOGY,235(11),3125-3135.
MLA Cao, Zeyuan,et al."Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital".PSYCHOPHARMACOLOGY 235.11(2018):3125-3135.

入库方式: OAI收割

来源:心理研究所

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