Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity
文献类型：期刊论文
| 作者 | Tang, Yang2,3; Zhao, Zhen-Zhu2; Yao, Jian-Neng2,3; Feng, Tao1; Li, Zheng-Hui1; Chen, He-Ping1; Liu, Ji-Kai1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 81期号:10页码:2163-2168 |
| ISSN号 | 0163-3864 |
| 英文摘要 | Five new triterpenoids, irpeksins A E (1-5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well as absolute configurations of the new compounds were established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1-4 are featured by a scaffold of 1,10-seco- and ring B aromatic eburicane (24-methyllanostane), and compound 5 is characterized by a scaffold of 1,10-9,11-diseco- and ring B aromatic eburicane, which represents unprecedented cleavage patterns in the lanostane family. Compounds 1-5 showed significant inhibitory activity against NO production in LPSactivated RAW 264.7 macrophage cells with IC50 values varying from 2.2 to 19.6 mu M. |
| 资助项目 | National Natural Science Foundation of China[81561148013] ; National Natural Science Foundation of China[81773590] ; National Key Technologies R&D Program of China[2017YFC1704007] ; Supercomputing Center of the Chinese Academy of Sciences in Beijing |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China ; National Key Technologies R&D Program of China ; Supercomputing Center of the Chinese Academy of Sciences in Beijing |
| 源URL | [http://ir.kib.ac.cn/handle/151853/63085]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Chen, He-Ping; Liu, Ji-Kai |
| 作者单位 | 1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Yang,Zhao, Zhen-Zhu,Yao, Jian-Neng,et al. Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(10):2163-2168. |
| APA | Tang, Yang.,Zhao, Zhen-Zhu.,Yao, Jian-Neng.,Feng, Tao.,Li, Zheng-Hui.,...&Liu, Ji-Kai.(2018).Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity.JOURNAL OF NATURAL PRODUCTS,81(10),2163-2168. |
| MLA | Tang, Yang,et al."Irpeksins A-E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity".JOURNAL OF NATURAL PRODUCTS 81.10(2018):2163-2168. |
入库方式： OAI收割
来源：昆明植物研究所
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