Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber
文献类型：期刊论文
| 作者 | Yang, Wenjiao; Cai, Ying; Yin, Ronghua; Lin, Lisha; Li, Zhongkun; Wu, Mingyi; Zhao, Jinhua
|
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 26页码:50-54 |
| 关键词 | Fucosylated glycosaminoglycan Fucan sulfate Polysaccharide Anticoagulant Sea cucumber |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.ijbiomac.2018.04.175 |
| 通讯作者 | Li, Zhongkun(yayylzk@163.com) ; Wu, Mingyi(wumingyi@mail.kib.ac.cn) ; Zhao, Jinhua(zhaojinhua@mail.kib.ac.cn) |
| 英文摘要 | Sulfated polysaccharides such as fucosylated glycosaminoglycan and fucan sulfate from echinoderm possess complex chemical structure and various biological activities. The two sulfated polysaccharides were purified from the low-value sea cucumber Holothuria coluber. Their physicochemical properties and chemical structures were analyzed and characterized by chemical and instrumental methods. Structural analysis clarified that the sea cucumber fucosylated glycosaminoglycan contains a chondroitin sulfate-like backbone and fucosyl branches with four various sulfation patterns. The fucan sulfate with molecular weight of 64.6 kDa comprises a central core of regular alpha(1 -> 4)-linked tetrasaccharide repeating units, each of which is linked by a 4-O-sulfated fucose residue. Anticoagulant assays indicated that these sulfated polysaccharides possessed strong APTT prolonging activities and intrinsic factor Xase inhibitory activities, both of which decreased with the reduction of their molecular weights. Our results expand knowledge on the structural types of sulfated polysaccharides from sea cucumbers and further illustrate their functionality. (C) 2018 Elsevier B.V. All rights reserved. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000438662500118 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/63320]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yang, Wenjiao,Cai, Ying,Yin, Ronghua,et al. Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber[J]. PHYTOCHEMISTRY LETTERS,2018,26:50-54. |
| APA | Yang, Wenjiao.,Cai, Ying.,Yin, Ronghua.,Lin, Lisha.,Li, Zhongkun.,...&Zhao, Jinhua.(2018).Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber.PHYTOCHEMISTRY LETTERS,26,50-54. |
| MLA | Yang, Wenjiao,et al."Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber".PHYTOCHEMISTRY LETTERS 26(2018):50-54. |
入库方式： OAI收割
来源：昆明植物研究所
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