Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer
文献类型：期刊论文
| 作者 | Vijay-Kumar, Matam1,14; Gewirtz, Andrew T.11; Patterson, Andrew D.8; Joe, Bina14; Kennett, Mary J.8; Xiong, Na8; Conejo-Garcia, Jose R.2; Cani, Patrice D.3; Gonzalez, David J.9; Flythe, Michael D.4 |
| 刊名 | CELL
 |
| 出版日期 | 2018-10-18 |
| 卷号 | 175期号:3页码:679-+ |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2018.09.004 |
| 英文摘要 | Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, induced icteric hepatocellular carcinoma (HCC). Such HCC was microbiota-dependent and observed in multiple strains of dysbiotic mice but not in germ-free nor antibiotics-treated mice. Furthermore, consumption of an inulin-enriched high-fat diet induced both dysbiosis and HCC in wild-type (WT) mice. Inulin-induced HCC progressed via early onset of cholestasis, hepatocyte death, followed by neutrophilic inflammation in liver. Pharmacologic inhibition of fermentation or depletion of fermenting bacteria markedly reduced intestinal SCFA and prevented HCC. Intervening with cholestyramine to prevent reabsorption of bile acids also conferred protection against such HCC. Thus, its benefits notwithstanding, enrichment of foods with fermentable fiber should be approached with great caution as it may increase risk of HCC. |
| WOS关键词 | CHAIN FATTY-ACIDS ; GUT MICROBIOTA ; METABOLIC SYNDROME ; HEPATOCELLULAR-CARCINOMA ; BETA-CATENIN ; RECEPTOR 5 ; MICE ; PROTECTS ; BACTERIA ; COLITIS |
| 资助项目 | NIH[R01CA219144] ; NIH[R03DK094864] ; NIH[R01DK097865] ; NIH[DK061417] ; NIH[DK083890] ; Crohn's and Colitis Foundation of America (CCFA) ; CCFA Career Development Award ; FRS-FNRS ; Funds Baillet Latour ; ERC[2013 (336452-ENIGMO)] ; [WELBIO-CGR-2017-C2] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000447780800012 |
| 资助机构 | NIH ; Crohn's and Colitis Foundation of America (CCFA) ; CCFA Career Development Award ; FRS-FNRS ; Funds Baillet Latour ; ERC ; NIH ; Crohn's and Colitis Foundation of America (CCFA) ; CCFA Career Development Award ; FRS-FNRS ; Funds Baillet Latour ; ERC ; NIH ; Crohn's and Colitis Foundation of America (CCFA) ; CCFA Career Development Award ; FRS-FNRS ; Funds Baillet Latour ; ERC ; NIH ; Crohn's and Colitis Foundation of America (CCFA) ; CCFA Career Development Award ; FRS-FNRS ; Funds Baillet Latour ; ERC |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/13158]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Vijay-Kumar, Matam |
| 作者单位 | 1.Univ Toledo, Dept Med Microbiol & Immunol, Toledo, OH 43614 USA 2.H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, Tampa, FL 33612 USA 3.Catholic Univ Louvain, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & Biotechnol, Brussels, Belgium 4.Univ Kentucky, USDA ARS, Lexington, KY 40546 USA 5.Penn State Univ, Dept Biomed Chem, State Coll, PA 16802 USA 6.State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Hubei, Peoples R China 7.Chinese Acad Sci, Wuhan, Hubei, Peoples R China 8.Penn State Univ, Dept Vet & Biomed Sci, State Coll, PA 16802 USA 9.Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92093 USA 10.Penn State Univ, Dept Nutr Sci, State Coll, PA 16802 USA |
| 推荐引用方式 GB/T 7714 | Vijay-Kumar, Matam,Gewirtz, Andrew T.,Patterson, Andrew D.,et al. Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer[J]. CELL,2018,175(3):679-+. |
| APA | Vijay-Kumar, Matam.,Gewirtz, Andrew T..,Patterson, Andrew D..,Joe, Bina.,Kennett, Mary J..,...&Singh, Vishal.(2018).Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.CELL,175(3),679-+. |
| MLA | Vijay-Kumar, Matam,et al."Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer".CELL 175.3(2018):679-+. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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