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Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis

文献类型：期刊论文

作者Ma, Chen1; Sun, Zheng3,4; Zeng, Benhua2; Huang, Shi3,4; Zhao, Jie1; Zhang, Yong1; Su, Xiaoquan3,4; Xu, Jian3,4; Wei, Hong5; Zhang, Heping1
刊名MICROBIOME
出版日期2018-11-08
卷号6页码:17
关键词Mastitis Intestinal microbiota Fecal microbiota transplantation Germ-free mice Probiotics
ISSN号2049-2618
DOI10.1186/s40168-018-0578-1
英文摘要BackgroundMastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, which however are of concern in both treatment efficacy and neonate safety. Here, using bovine mastitis which is the most costly disease in the dairy industry as a model, we showed that intestinal microbiota alone can lead to mastitis.ResultsFecal microbiota transplantation (FMT) from mastitis, but not healthy cows, to germ-free (GF) mice resulted in mastitis symptoms in mammary gland and inflammations in serum, spleen, and colon. Probiotic intake in parallel with FMT from diseased cows led to relieved mastitis symptoms in mice, by shifting the murine intestinal microbiota to a state that is functionally distinct from either healthy or diseased microbiota yet structurally similar to the latter. Despite conservation in mastitis symptoms, diseased cows and mice shared few mastitis-associated bacterial organismal or functional markers, suggesting striking divergence in mastitis-associated intestinal microbiota among lactating mammals. Moreover, an amplification effect of disease-health distinction in both microbiota structure and function was apparent during the cow-to-mouse FMT.ConclusionsHence, dysbiosis of intestinal microbiota may be one cause of mastitis, and probiotics that restore intestinal microbiota function are an effective and safe strategy to treat mastitis.
WOS关键词LACTOBACILLUS-CASEI ZHANG ; NF-KAPPA-B ; CLINICAL MASTITIS ; MOLECULAR EPIDEMIOLOGY ; STREPTOCOCCUS-UBERIS ; ANTIBIOTIC-TREATMENT ; BOVINE MASTITIS ; READ ALIGNMENT ; DAIRY-CATTLE ; MODEL
资助项目National Natural Science Foundation of China[31400089] ; China Postdoctoral Science Foundation[2016LH00036]
WOS研究方向Microbiology
语种英语
WOS记录号WOS:000449968500002
出版者BMC
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation
源URL[http://ir.qibebt.ac.cn/handle/337004/11043]  
专题中国科学院青岛生物能源与过程研究所
通讯作者Xu, Jian; Wei, Hong; Zhang, Heping
作者单位1.Inner Mongolia Agr Univ, Key Lab Dairy Biotechnol & Engn, Hohhot 010018, Peoples R China
2.Third Mil Med Univ, Dept Lab Anim Sci, Coll Basic Med Sci, Chongqing 400038, Peoples R China
3.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Single Cell Ctr, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China
4.Chinese Acad Sci, Shandong Key Lab Energy Genet, Qingdao Inst BioEnergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China
5.Huazhong Agr Univ, Engn Technol Res Ctr Germ Free & Genome Editing A, Wuhan 430070, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Chen,Sun, Zheng,Zeng, Benhua,et al. Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis[J]. MICROBIOME,2018,6:17.
APA Ma, Chen.,Sun, Zheng.,Zeng, Benhua.,Huang, Shi.,Zhao, Jie.,...&Zhang, Heping.(2018).Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis.MICROBIOME,6,17.
MLA Ma, Chen,et al."Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis".MICROBIOME 6(2018):17.

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来源：青岛生物能源与过程研究所

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