First characterization of two C-type lectins of the tubeworm Alaysia sp from a deep-sea hydrothermal vent
文献类型：期刊论文
| 作者 | Jin, Qian-wen1,2,3; Sun, Qing-lei1,2; Zhang, Jian1,2; Sun, Li1,2 |
| 刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 86页码:17-25 |
| 关键词 | C-type Lectin Alaysia Sp. Deep-sea Hydrothermal Vent Antibacterial Hemagglutination |
| ISSN号 | 0145-305X |
| DOI | 10.1016/j.dci.2018.04.019 |
| 文献子类 | Article |
| 英文摘要 | C-type lectins (CTLs) play an important role in innate immune defense. In this study, we identified and characterized two CTLs (Lec1 and Lec2) from the tubeworm Alaysia sp. collected from a hydrothermal vent in Pacmanus. Lec1 and Lec2 possess the typical CTL domain but share low sequence identities (10.8% -20.4%) with known CTLs. Recombinant (r) of Lec1 and Lec2 bound to various PAMPs and a wide arrange of bacteria from neritic and deep-sea environments in a Ca2+-independent manner, but only rLec1 caused agglutination of the bound bacteria. The activities of rLec1 and rLec2 were most stable and highest at 4 degrees C, the ambient temperature of the hydrothermal vent, and decreased at higher temperatures. Both lectins inhibited bacterial growth in a highly selective manner and agglutinated the erythrocytes of fish, rabbit, and chicken in a Ca2+-dependent manner. These results provided the first insights into the functional properties of CTLs in deep-sea Alaysia sp. (C) 2018 Elsevier Ltd. All rights reserved. |
| WOS关键词 | INNATE IMMUNITY ; RIDGEIA-PISCESAE ; SINGLE CRD ; BACTERIAL ; ANTIBACTERIAL ; RECOGNITION ; PROTEIN ; EXPRESSION ; INFECTION ; DEFENSE |
| WOS研究方向 | Fisheries ; Immunology ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:000435060900003 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | Qingdao National Laboratory for Marine Science and Technology(QNLM2016ORP0309) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA11030401) ; Taishan Scholar Program of Shandong Province |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/11375]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Sun, Qing-lei |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Qian-wen,Sun, Qing-lei,Zhang, Jian,et al. First characterization of two C-type lectins of the tubeworm Alaysia sp from a deep-sea hydrothermal vent[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,86:17-25. |
| APA | Jin, Qian-wen,Sun, Qing-lei,Zhang, Jian,&Sun, Li.(2018).First characterization of two C-type lectins of the tubeworm Alaysia sp from a deep-sea hydrothermal vent.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,86,17-25. |
| MLA | Jin, Qian-wen,et al."First characterization of two C-type lectins of the tubeworm Alaysia sp from a deep-sea hydrothermal vent".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 86(2018):17-25. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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