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Deciphering the late steps of rifamycin biosynthesis

文献类型：期刊论文

作者Qi, Feifei1; Lei, Chao2; Li, Fengwei1; Zhang, Xingwang1; Wang, Jin2; Zhang, Wei1; Fan, Zhen2; Li, Weichao2; Tang, Gong-Li3; Xiao, Youli2,4
刊名NATURE COMMUNICATIONS
出版日期2018-06-14
卷号9
ISSN号2041-1723
DOI10.1038/s41467-018-04772-x
文献子类Article
英文摘要Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit transketolase Rif15 and the cytochrome P450 enzyme Rif16 are found to mediate, respectively, a unique C-O bond formation in rifamycin L and an atypical P450 ester-to-ether transformation from rifamycin L to B. Both reactions showcase interesting chemistries for these two widespread and well-studied enzyme families.
WOS关键词AMYCOLATOPSIS-MEDITERRANEI S699 ; GENE-CLUSTER ; SP NOV. ; CYTOCHROME-P450 ; P450 ; TRANSKETOLASE ; SEQUENCE ; PROTEIN ; SV ; TRANSFORMATION
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000435341000006
资助机构Shandong Provincial Natural Science Foundation(ZR2017ZB0207) ; National Natural Science Foundation of China(81741155 ; Chinese Academy of Sciences(QYZDB-SSW-SMC042 ; Science and Technology Commission of Shanghai Municipality(15JC1400402) ; 31422002 ; XDPB0402) ; 21472204 ; 31600036 ; 21572243 ; 31430004 ; 31670058)
源URL[http://ir.qibebt.ac.cn/handle/337004/11379]  
专题中国科学院青岛生物能源与过程研究所
通讯作者Xiao, Youli; Li, Shengying
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, Shandong Prov Key Lab Synthet Biol, Qingdao 266101, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Plant Physiol & Ecol, Shanghai Inst Biol Sci, CAS Key Lab Synthet Biol, Shanghai 200032, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Feifei,Lei, Chao,Li, Fengwei,et al. Deciphering the late steps of rifamycin biosynthesis[J]. NATURE COMMUNICATIONS,2018,9.
APA Qi, Feifei.,Lei, Chao.,Li, Fengwei.,Zhang, Xingwang.,Wang, Jin.,...&Li, Shengying.(2018).Deciphering the late steps of rifamycin biosynthesis.NATURE COMMUNICATIONS,9.
MLA Qi, Feifei,et al."Deciphering the late steps of rifamycin biosynthesis".NATURE COMMUNICATIONS 9(2018).

入库方式： OAI收割

来源：青岛生物能源与过程研究所

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