中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity

文献类型:期刊论文

作者Liu, Huaide1; Wang, Jing2,3,4; Zhang, Quanbin2,3; Zhang, Hong2,3
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2018-07-01
卷号113页码:82-89
ISSN号0141-8130
关键词Fucoidan Derivatives Molecular Weights Substitute Group Neuroprotective Anticomplement
DOI10.1016/j.ijbiomac.2018.02.109
文献子类Article
英文摘要Ten fucoidan (FPS) derivatives were successfully synthesized, and their potential neuroprotective and anticomplement activities were investigated employing various established in vitro systems. The aim of the present study was to investigate the effects of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activities. All FPS derivatives possessed considerable neuroprotective and anticomplement activities and had stronger activities than FPS in certain tests. The in vitro results found that sulfated and benzoylated derivatives could reverse the decreased mitochondrial activity and decreased lactate dehydrogenase (LDH) and reactive oxygen species (ROS) release induced by 6-hydroxydopamine (6-OHDA, P < 0.01 or P < 0.001), which provides further evidence that sulfate and benzoylate groups could enhance the neuroprotective activity of fucoidan. In anticomplement experiments, all samples showed anticomplement activity in both systems; however, the sulfated and benzoylated derivatives showed better activity than fucoidan, with higher molecular weights showing the strongest activity. Available data suggested that substituted groups of fucoidan played an important role on neuroprotective and anticomplement activities. The mechanism of the influence of the neuroprotective and anticomplement activities of samples of the substituted groups was indicated. (C) 2018 Published by Elsevier B.V.
WOS关键词ACTIVITY IN-VITRO ; ANTIOXIDANT ACTIVITY ; LAMINARIA-JAPONICA ; PARKINSONS-DISEASE ; MITOCHONDRIAL DYSFUNCTION ; ANTI-COMPLEMENT ; BROWN SEAWEED ; DERIVATIVES ; POLYSACCHARIDES ; ACTIVATION
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
出版者ELSEVIER SCIENCE BV
WOS记录号WOS:000432503100011
资助机构Fujian the Science and Technology Project of Fujian Province(2017T3015) ; Science and Technology Project of Shandong Province(2016GSF115031) ; Open Fund Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology(0F2015N007) ; Youth Innovation Promotion Association of CAS(2016190) ; Natural Science Foundation of China (NSFC)(41406144) ; Natural Science Foundation of the Jiangsu Higher Education Institutions of China(15KJB170016)
源URL[http://ir.qibebt.ac.cn/handle/337004/11451]  
专题中国科学院青岛生物能源与过程研究所
通讯作者Wang, Jing
作者单位1.Nantong Univ, Sch Ocean, Sch Life Sci, Nantong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Nantong Branch, Nantong, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Liu, Huaide,Wang, Jing,Zhang, Quanbin,et al. The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,113:82-89.
APA Liu, Huaide,Wang, Jing,Zhang, Quanbin,&Zhang, Hong.(2018).The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,113,82-89.
MLA Liu, Huaide,et al."The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 113(2018):82-89.

入库方式: OAI收割

来源:青岛生物能源与过程研究所

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