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TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways

文献类型：期刊论文

作者Yin, Nuoya1,2; Liang, Shaojun1,2; Liang, Shengxian1,2; Yang, Renjun1,2; Hu, Bowen1,2; Qin, Zhanfen1,2; Liu, Aifeng3; Faiola, Francesco1,2
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
出版日期2018-05-01
卷号52期号:9页码:5459-5468
ISSN号0013-936X
DOI10.1021/acs.est.8b00414
文献子类Article
英文摘要Tetrabromobisphenol A (TBBPA), as well as its alternatives Tetrabromobisphenol S (TBBPS) and Tetrachlorobisphenol A (TCBPA), are widely used halogenated flame retardants. Their high detection rates in human breast milk and umbilical cord serum have raised wide concerns about their adverse effects on human fetal development. In this study, we evaluated the cytotoxicity and neural developmental toxicity of TBBPA, TBBPS, and TCBPA with a mouse embryonic stem cell (mESC) system, at human body fluid and environmental relevant doses. All the three compounds showed similar trends in their cytotoxic effects. However, while TBBPA and TBBPS stimulated ESC neural differentiation, TCBPA significantly inhibited neurogenesis. Mechanistically, we demonstrated that, as far as the NOTCH (positive regulator) and WNT (negative regulator) pathways were concerned, TBBPA only partially and slightly disturbed them, whereas TBBPS significantly inhibited the WNT pathway, and TCBPA down-regulated the expression of NOTCH effectors but increased the WNT signaling, actions which both inhibited neural specification. In conclusion, our findings suggest that TBBPS and TCBPA may not be safe alternatives to TBBPA, and their toxicity need to be comprehensively evaluated.
WOS关键词EMBRYONIC STEM-CELLS ; TETRABROMOBISPHENOL-A TBBPA ; CEREBELLAR GRANULE CELLS ; ONE-GENERATION REPRODUCTION ; BROMINATED FLAME-RETARDANT ; FREE-RADICAL FORMATION ; IN-VITRO ; BISPHENOL-A ; LARVAL ZEBRAFISH ; OXIDATIVE STRESS
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000431466500045
出版者AMER CHEMICAL SOC
资助机构Chinese Academy of Sciences Strategic Priority Research Program(XDB14040301) ; National Natural Science Foundation of China(21577166 ; Chinese Academy of Sciences Hundred Talent Program(29[2015]30) ; Key Research Program of Frontier Sciences, CAS(QYZDJ-SSW-DQC017) ; 21461142001)
源URL[http://ir.qibebt.ac.cn/handle/337004/11519]  
专题中国科学院青岛生物能源与过程研究所
通讯作者Faiola, Francesco
作者单位1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Biomass Energy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
推荐引用方式
GB/T 7714		 Yin, Nuoya,Liang, Shaojun,Liang, Shengxian,et al. TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(9):5459-5468.
APA Yin, Nuoya.,Liang, Shaojun.,Liang, Shengxian.,Yang, Renjun.,Hu, Bowen.,...&Faiola, Francesco.(2018).TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways.ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(9),5459-5468.
MLA Yin, Nuoya,et al."TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.9(2018):5459-5468.

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来源：青岛生物能源与过程研究所

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