Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas
文献类型：期刊论文
| 作者 | Song, Kai1,2,3; Li, Li1,3,4,5; Zhang, Guofan1,2,3,5 |
| 刊名 | MARINE BIOTECHNOLOGY
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 20期号:5页码:676-684 |
| 关键词 | Single nucleotide polymorphism (SNP) Recombination rates Purifying selection |
| ISSN号 | 1436-2228 |
| DOI | 10.1007/s10126-018-9838-0 |
| 英文摘要 | Crassostrea gigas is a model mollusk, but its genetic features have not been studied comprehensively. In this study, we used whole-genome resequencing data to identify and characterize nucleotide diversity and population recombination rate in a diverse collection of 21 C. gigas samples. Our analyses revealed that C. gigas harbors both extremely high genetic diversity and recombination rates across the whole genome as compared with those of the other taxa. The noncoding regions, introns, intergenic spacers, and untranslated regions (UTRs) showed a lower level diversity than the synonymous sites. The larger introns tended to have lower diversity. Moreover, we found a negative association of the non-synonymous diversity with gene expression, which suggested that purifying selection played an important role in shaping genetic diversity. The nucleotide diversity at the 100- and 50-kb levels was positively correlated with population recombination rates, which was expected if the diversity was shaped by purifying selection or hitchhiking of advantageous mutants. Our work gives a general picture of the oyster's polymorphism pattern and its association with recombination rates. |
| WOS关键词 | NEUTRAL MOLECULAR VARIATION ; DNA-SEQUENCE POLYMORPHISM ; ARABIDOPSIS-THALIANA ; LINKAGE DISEQUILIBRIUM ; EVOLUTIONARY PATTERNS ; RECOMBINATION RATE ; DROSOPHILA ; GENOME ; SELECTION ; REVEALS |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000444297400012 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/11819]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Li, Li; Zhang, Guofan |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China 3.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries & Aquaculture, Qingdao 266071, Shandong, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, 7th Nanhai Rd, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Kai,Li, Li,Zhang, Guofan. Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas[J]. MARINE BIOTECHNOLOGY,2018,20(5):676-684. |
| APA | Song, Kai,Li, Li,&Zhang, Guofan.(2018).Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas.MARINE BIOTECHNOLOGY,20(5),676-684. |
| MLA | Song, Kai,et al."Relationship Among Intron Length, Gene Expression, and Nucleotide Diversity in the Pacific Oyster Crassostrea gigas".MARINE BIOTECHNOLOGY 20.5(2018):676-684. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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