Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids
文献类型：期刊论文
| 作者 | Zou, Huibin1,2; Zhang, Tongtong1; Li, Lei1; Huang, Jingling1; Zhang, Nan1; Shi, Mengxun1; Hao, He1; Xian, Mo2
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| 刊名 | MATERIALS
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| 出版日期 | 2018-08-01 |
| 卷号 | 11期号:8页码:14 |
| ISSN号 | 1996-1944 |
| 关键词 | biosynthesis carbon economy polyhydroxyalkanoates isoprenoids |
| DOI | 10.3390/ma11081271 |
| 英文摘要 | With the rapid development of synthetic biology and metabolic engineering, a broad range of biochemicals can be biosynthesized, which include polyhydroxyalkanoates and isoprenoids. However, some of the bio-approaches in chemical synthesis have just started to be applied outside of laboratory settings, and many require considerable efforts to achieve economies of scale. One of the often-seen barriers is the low yield and productivity, which leads to higher unit cost and unit capital investment for the bioconversion process. In general, higher carbon economy (less carbon wastes during conversion process from biomass to objective bio-based chemicals) will result in higher bioconversion yield, which results in less waste being generated during the process. To achieve this goal, diversified strategies have been applied; matured strategies include pathway engineering to block competitive pathways, enzyme engineering to enhance the activities of enzymes, and process optimization to improve biomass/carbon yield. In this review, we analyze the impact of carbon sources from different types of biomass on the yield of bio-based chemicals (especially for polyhydroxyalkanoates and isoprenoids). Moreover, we summarize the traditional strategies for improving carbon economy during the bioconversion process and introduce the updated techniques in building up non-natural carbon pathways, which demonstrate higher carbon economies than their natural counterparts. |
| WOS关键词 | RECOMBINANT ESCHERICHIA-COLI ; POLY-BETA-HYDROXYBUTYRATE ; FED-BATCH CULTIVATION ; SACCHAROMYCES-CEREVISIAE ; POLY(3-HYDROXYBUTYRATE) PRODUCTION ; ALCALIGENES-EUTROPHUS ; MICROBIAL-PRODUCTION ; RALSTONIA-EUTROPHA ; BIODEGRADABLE POLYHYDROXYALKANOATES ; PELOBACTER-CARBINOLICUS |
| 资助项目 | Shandong Province Natural Science Foundation[ZR2015BM011] ; Technology Development Project of Shandong Province[2016GSF121013] ; National Natural Science Foundation[21376156] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000444112800008 |
| 资助机构 | Shandong Province Natural Science Foundation ; Technology Development Project of Shandong Province ; National Natural Science Foundation |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/11831]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Zou, Huibin |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Huibin,Zhang, Tongtong,Li, Lei,et al. Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids[J]. MATERIALS,2018,11(8):14. |
| APA | Zou, Huibin.,Zhang, Tongtong.,Li, Lei.,Huang, Jingling.,Zhang, Nan.,...&Xian, Mo.(2018).Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids.MATERIALS,11(8),14. |
| MLA | Zou, Huibin,et al."Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids".MATERIALS 11.8(2018):14. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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