AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis
文献类型：期刊论文
| 作者 | Li, Qinglian1; Ding, Wenjuan1,2; Yao, Ziwei1,2; Tu, Jiajia1; Wang, Liyan3; Huang, Hongbo1; Li, Shengying4 ; Ju, Jianhua1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2018-08-17 |
| 卷号 | 20期号:16页码:4854-4857 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.8b01997 |
| 英文摘要 | Members of the abyssomicin class of natural products are characterized by a novel vinylic bridged ether ring. In this study, in vivo gene inactivation, structure elucidation of the accumulated intermediate abyssomicin 6, and in vitro enzyme assays enabled the identification of a cytochrome P450 enzyme, AbmV. AbmV carries out domino reactions involving bridged ether installation and C-11 hydroxylation during the biosynthesis of neoabyssomicins/abyssomicins in S. koyangensis SCSIO 5802. |
| WOS关键词 | MARINE VERRUCOSISPORA STRAIN ; KOYANGENSIS SCSIO 5802 ; CYTOCHROME-P450 MONOOXYGENASE ; ABYSSOMICIN-C ; STREPTOMYCES ; P450 ; POLYKETIDE ; EXPRESSION ; AB-18-032 ; PATHWAY |
| 资助项目 | China NSF[31670087] ; China NSF[81425022] ; China NSF[U1501223] ; China NSF[U1706206] ; China NSF[41476133] ; CAS[XDA11030403] ; CAS[XDA13020302-2] ; Guangdong NSF[2016A030312014] ; Pearl River S&T Nova Program of Guangzhou[201806010109] ; Special Support Program for Training High-Level Talents in Guangdong[2016TQ03R288] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000442454900030 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | China NSF ; CAS ; Guangdong NSF ; Pearl River S&T Nova Program of Guangzhou ; Special Support Program for Training High-Level Talents in Guangdong |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/11990]  |
| 专题 | 中国科学院青岛生物能源与过程研究所 |
| 通讯作者 | Li, Qinglian; Ju, Jianhua |
| 作者单位 | 1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.Shenzhen Univ, Coll Bio & Marine Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, CAS Key Lab Biofuels, Qingdao 266000, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qinglian,Ding, Wenjuan,Yao, Ziwei,et al. AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis[J]. ORGANIC LETTERS,2018,20(16):4854-4857. |
| APA | Li, Qinglian.,Ding, Wenjuan.,Yao, Ziwei.,Tu, Jiajia.,Wang, Liyan.,...&Ju, Jianhua.(2018).AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis.ORGANIC LETTERS,20(16),4854-4857. |
| MLA | Li, Qinglian,et al."AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis".ORGANIC LETTERS 20.16(2018):4854-4857. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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