Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect
文献类型：期刊论文
| 作者 | Peng, Feng1; Wang, Donghui1; Cao, Huiliang; Liu, Xuanyon |
| 刊名 | MATERIALS LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 213页码:383 |
| 关键词 | Biomaterials Functional Corrosion Surfaces Thin films |
| ISSN号 | 0167-577X |
| DOI | 10.1016/j.matlet.2017.11.007 |
| 英文摘要 | The clinic application of magnesium is mainly impeded by its poor corrosion resistance and implants with localized drug delivery attract tremendous interest. Here, Mg/Al layered double hydroxide (Mg-Al LDH) film was in situ prepared on AZ31 alloy by a hydrothermal process, and further calcined to form metastable mixed oxides, also named Mg/Al layered double oxide (LDO). Finally, immersing in 5Fluorouracil (5-FU) solution, Mg/Al LDO would revert to Mg/Al LDH via a memory effect, and be loaded with 5-FU (#LDO-5FU). Comparing to AZ31 alloy, the corrosion resistance of the as-prepared #LDO-5FU sample was enhanced. The amount of released 5-FU from # LDO-5FU sample was similar to 993 ng/cm(2). The proliferation of human cholangiocarcinoma cell (RBE) was effectively inhibited on the surface of # LDO-5FU sample owing to the release of 5-FU. This work broadens the application of calcined LDH and provides a new strategy in the field of surface modification of magnesium alloy. (C) 2017 Elsevier B.V. All rights reserved. |
| 学科主题 | Materials Science, Multidisciplinary ; Physics, Applied |
| WOS记录号 | WOS:000419049300096 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | This work is financially supported by National Natural Science Foundation of China (31771044, 31370962), the National Key Research and Development Program of China No. 2016YFC1100604, Shanghai Committee of Science and Technology, China (15441904900). ; This work is financially supported by National Natural Science Foundation of China (31771044, 31370962), the National Key Research and Development Program of China No. 2016YFC1100604, Shanghai Committee of Science and Technology, China (15441904900). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24482]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Feng,Wang, Donghui,Cao, Huiliang,et al. Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect[J]. MATERIALS LETTERS,2018,213:383, 386. |
| APA | Peng, Feng,Wang, Donghui,Cao, Huiliang,&Liu, Xuanyon.(2018).Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect.MATERIALS LETTERS,213,383. |
| MLA | Peng, Feng,et al."Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect".MATERIALS LETTERS 213(2018):383. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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