3D Printed Fe Scaffolds with HA Nanocoating for Bone Regeneration
文献类型：期刊论文
| 作者 | Yang, Chen1; Huan, Zhiguang; Wang, Xiaoya; Wu, Chengtie; Chang, Jiang |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2018 |
| 卷号 | 4期号:2页码:608 |
| 关键词 | 3D printing HA nanocoating bone scaffold tissue engineering |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.7b00885 |
| 英文摘要 | Pure iron (Fe) has been investigated as a cardiovascular stent in recent years for its biodegradation property and blood compatibility. It also has great potential for bone healing, especially for load-bearing areas based on its inherent mechanical property which is high enough for bone regeneration. However, the conventional manufacturing methods restrict its application as bone scaffold for uncontrollable architecture and stiffness. Also, the cytotoxicity makes it impossible for in vitro culture as bone tissue engineering scaffold. To solve these deficiencies, in the present study, we applied 3D printing technique with a modified coating strategy together to precisely control the macropore structure and surface nanostructure of final scaffolds. Our results showed that the compressive mechanical properties of the 3D printed Fe scaffolds were in the natural bone range and the hydroxyapatite (HA) coating was highly bonded to the substrate, significantly improved the viability and alkaline phosphatase (ALP) activity and osteogenic differentiation of the rabbit bone marrow mesenchymal stem cells (rBMSCs) on the scaffold. This study indicates that the 3D printed Fe scaffolds with controllable nanostructured HA coating may be a promising candidate for bone tissue engineering applications. |
| 学科主题 | Materials Science, bioMaterials |
| WOS记录号 | WOS:000425194500033 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Funding for this study was provided by National Key Research and Development Program of China (2016YFB0700803), Natural Science Foundation of China (Grant 81430012, 81190132, 81671830, 31370963), Key Research Program of Frontier Sciences,CAS (QYZDB-SSW-SYS027) and Program of Shanghai Outstanding Academic Leaders (15XD1503900). ; Funding for this study was provided by National Key Research and Development Program of China (2016YFB0700803), Natural Science Foundation of China (Grant 81430012, 81190132, 81671830, 31370963), Key Research Program of Frontier Sciences,CAS (QYZDB-SSW-SYS027) and Program of Shanghai Outstanding Academic Leaders (15XD1503900). |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24509]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Chen,Huan, Zhiguang,Wang, Xiaoya,et al. 3D Printed Fe Scaffolds with HA Nanocoating for Bone Regeneration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(2):608, 616. |
| APA | Yang, Chen,Huan, Zhiguang,Wang, Xiaoya,Wu, Chengtie,&Chang, Jiang.(2018).3D Printed Fe Scaffolds with HA Nanocoating for Bone Regeneration.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(2),608. |
| MLA | Yang, Chen,et al."3D Printed Fe Scaffolds with HA Nanocoating for Bone Regeneration".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.2(2018):608. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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