Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing
文献类型：期刊论文
| 作者 | Qian, Wenhao2; Qiu, Jiajun1,3; Su, Jiansheng; Liu, Xuanyong1 |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:2页码:304 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/c7bm00931c |
| 英文摘要 | Titanium and its alloys have been widely used in orthopedic and dental implants because of their excellent properties. However, implant failures still occur due to implant-associated bacterial infections. Therefore, proper surface modification of titanium and its alloys is necessary. In this work, commercial pure titanium plates were modified with graphene oxide (GO) which was used to load minocycline hydrochloride. Gram-positive Staphylococcus aureus (S. aureus) and Streptococcus mutans (S. mutans) and Gram-negative Escherichia coli (E. coli) were used to investigate the antibacterial activity of the samples. Human gingival fibroblast (HGF) cells were applied to assess the cytocompatibility of the various samples. To investigate cell adhesion and cell surface coverage in the presence of bacteria, the coculture of HGF cells and S. aureus was performed. The results indicated that the GO-modified titanium surface could inhibit the growth of the bacteria which had direct contact with GO, while it could not affect the bacteria without direct contact of GO. Minocycline hydrochloride on the GO-modified titanium surface (M@GO-Ti) showed a slow release behavior and exhibited excellent antibacterial activity with the synergistic effect of contact-killing and release-killing by GO and minocycline hydrochloride, respectively. In the coculture process with the presence of S. aureus, HGF cells on M@GO-Ti demonstrated the best cell viability and cell surface coverage among all the samples. |
| 学科主题 | Materials Science, bioMaterials |
| WOS记录号 | WOS:000423742400006 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | Financial support from the National Science Foundation for Distinguished Young Scholars of China (51525207), the National Natural Science Foundation of China (81371949 and 81572114), the Natural Science Foundation of Shanghai (17ZR1426700), the Shanghai Committee of Science and Technology, China (17441904000, 13411951201, and 17140903600), the Scientific Research Project of Science and Technology Commission of Xuhui Municipality (SHXH201613) is acknowledged. ; Financial support from the National Science Foundation for Distinguished Young Scholars of China (51525207), the National Natural Science Foundation of China (81371949 and 81572114), the Natural Science Foundation of Shanghai (17ZR1426700), the Shanghai Committee of Science and Technology, China (17441904000, 13411951201, and 17140903600), the Scientific Research Project of Science and Technology Commission of Xuhui Municipality (SHXH201613) is acknowledged. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/24517]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Tongji Univ, Sch Stomatol, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Dept Prosthodont, Shanghai 200072, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Shanghai Xuhui Dist Dent Ctr, Shanghai 200032, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Wenhao,Qiu, Jiajun,Su, Jiansheng,et al. Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing[J]. BIOMATERIALS SCIENCE,2018,6(2):304, 313. |
| APA | Qian, Wenhao,Qiu, Jiajun,Su, Jiansheng,&Liu, Xuanyong.(2018).Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing.BIOMATERIALS SCIENCE,6(2),304. |
| MLA | Qian, Wenhao,et al."Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing".BIOMATERIALS SCIENCE 6.2(2018):304. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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